Tijjani Adam
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Tijjani Adam
Official Name
Tijjani, Adam
Alternative Name
Adam, T.
Adama, Tijjani
Adam, Tijjani
Adam, Tijjan
Tijjani, A.
Main Affiliation
Scopus Author ID
55074964600
Researcher ID
AAH-5534-2019

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  • Publication
    Molecular-imprinting assisted polydopamine-aptasensor on carbon and gold nanomaterials construct for the haemophilia B biomarker detection
    ( 2024-06)
    Hemavathi Krishnan
    ;
    Subash Chandra Bose Gopinath
    ;
    Tijjani Adam
    ;
    Makram A. Fakhri
    ;
    Evan T. Salim
    ;
    Narendra Patil
    The study presents a comprehensive approach for enhancing the performance of a spiral micro-interdigitated electrode (spiral-μIDE) sensor for the detection of FIX protein. Electropolymerization using dopamine resulted in a molecular-imprinted polymer (polyDOP-μIDE-MIP) layer, which encapsulated the aptamer-FIX complex and was later leached to create cavities. Cyclic and linear-sweep voltammetry techniques were utilized for the MIP development and rebinding assessment. Linear sweep voltammetry demonstrated a linear relationship between FIX concentration and peak current reduction, with a limit of detection (LOD) of 0.250 picomolar. The sensor's sensitivity was determined as 2.613E-10 A.fM-1.μm-2. This work highlights the importance of nanomaterials integration, and electropolymerization in improving sensor performance. The integration of carbon and gold nanomaterials and the use of molecular imprinting contribute to the sensor's enhanced sensitivity and selective detection of FIX protein.
  • Publication
    Comparative analysis on aluminium interdigitated electrode surface influence of ionic strength and electrolytes changes
    ( 2024-06)
    Hussaini Adam
    ;
    Subash Chandra Bose Gopinath
    ;
    Tijjani Adam
    ;
    Makram A. Fakhri
    ;
    Evan T. Salim
    ;
    Uda Hashim
    The field of generating surface thin films in sensing applications is emerging, and the incorporation of thin film technology into sensor development for enhanced sensing is becoming increasingly significant in various industries such as healthcare, environmental monitoring, and food safety. However, in order to achieve higher specificity in biosensing, advances in nanomaterial biofunctionalization are crucial. This research focuses on the fabrication and characterization of nanobiosensors with surface modification using two different sensing materials: zinc oxide and gold nanorod nanocomposites. The aim of this study was to enhance the sensing capabilities of nanobiosensors by incorporating surface modification with different sensing materials. The fabrication of nanobiosensors involved using silicon as the base material and conventional photolithography to fabricate aluminium interdigitated electrodes with three different structures and gap sizes. AutoCAD software was utilized to create three different photo masks with varying gap sizes. Physical characterization of the fabricated ALIDEs was conducted using atomic force microscope, high power microscope, scanning electron microscope, and 3D-profilormeter. The electrical characterization of the ALIDEs was performed using a Keithley 6487 picoammeter. I-V measurements were conducted on bare ALIDEs as well as surface modified ALIDEs with zinc oxide and gold nanorod. I-V measurements were also performed for pH scouting. The I-V measurements on bare ALIDEs revealed that ALIDEs modified with gold nanorod conducted the least current compared to ALIDEs modified with zinc oxide. Furthermore, the ALIDEs modified with gold nanorod were found to be stable under various electrolytes environments after undergoing pH scouting.
  • Publication
    Arthropods-mediated green synthesis of Zinc oxide nanoparticles using cellar spider extract a biocompatible remediation for environmental approach
    ( 2024-06)
    Muzamir Isa
    ;
    Muhammad Nur Aiman Uda
    ;
    M. A. R. Irfan
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Hafiza Shukor
    ;
    MRM Huzaifah
    ;
    Maimunah Mohd Ali
    ;
    Nur Hulwani Ibrahim
    ;
    Muaz Mohd Zaini Makhtar
    ;
    Ng Qi Hwa
    ;
    Mohd Khairul Rabani Hashim
    ;
    Zainal Abidin Arsat
    ;
    Nor Azizah Parmin
    ;
    Liyana Ahmad Sofri
    ;
    Mahfuz Affif Mohd Ruslan
    ;
    Tijjani Adam
    This study presents an eco-friendly approach to synthesizing zinc oxide nanoparticles (ZnO NPs) using extracts from cellar spiders, addressing environmental and health concerns associated with conventional methods. The spider extract efficiently reduced zinc acetate dihydrate, and the synthesized ZnO NPs underwent comprehensive quantitative characterization, including size, shape, morphology, surface chemistry, thermal stability, and optical properties using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), zeta potential measurements, thermogravimetric analysis (TGA), and UV-vis spectroscopy. The nanoparticles exhibited intended characteristics, and their adsorption capability for methylene blue (MB) was quantitatively assessed using the Freundlich isotherm model and pseudo-second-order kinetic model, providing numerical insights into MB removal efficiency. The study demonstrates the potential of these green-synthesized ZnO NPs for applications in environmental remediation, wastewater treatment, and antibacterial therapies, contributing to both sustainable nanomaterial development and quantitative understanding of their functional properties.
  • Publication
    Silica and graphene mediate arsenic detection in mature rice grain by a newly patterned current–volt aptasensor
    ( 2021)
    M. N. A. Uda
    ;
    Subash Chandra Bose Gopinath
    ;
    Uda Hashim
    ;
    N. H. Halim
    ;
    N. A. Parmin
    ;
    M. N. Afnan Uda
    ;
    Tijjani Adam
    ;
    Periasamy Anbu
    Arsenic is a major global threat to the ecosystem. Here we describe a highly accurate sensing platform using silica nanoparticles/graphene at the surface of aluminum interdigitated electrodes (Al IDE), able to detect trace amounts of arsenic(III) in rice grain samples. The morphology and electrical properties of fabricated Al IDEs were characterized and standardized using AFM, and SEM with EDX analyses. Micrometer scale Al IDEs were fabricated with silicon, aluminum, and oxygen as primary elements. Validation of the bare Al IDE with electrolyte fouling was performed at different pH levels. The sensing surface was stable with no electrolyte fouling at pH 7. Each chemical modification step was monitored with current–volt measurement. The surface chemical bonds were characterized by fourier transform infrared spectroscopy (FTIR) and revealed different peaks when interacting with arsenic (1600–1000 cm−1). Both silica nanoparticles and graphene presented a sensitive limit of detection as measured by slope calibration curves at 0.0000001 pg/ml, respectively. Further, linear regression was established using ΔI (A) = 3.86 E−09 log (Arsenic concentration) [g/ml] + 8.67 E−08 [A] for silica nanoparticles, whereas for graphene Y = 3.73 E−09 (Arsenic concentration) [g/ml] + 8.52 E−08 on the linear range of 0.0000001 pg/ml to 0.01 pg/ml. The R2 for silica (0.96) and that of graphene (0.94) was close to the maximum (1). Modification with silica nanoparticles was highly stable. The potential use of silica nanoparticles in the detection of arsenic in rice grain extract can be attributed to their size and stability.
  • Publication
    Analysis on silica and graphene nanomaterials obtained from rice straw for antimicrobial potential
    ( 2024-06)
    Muhammad Nur Aiman Uda
    ;
    N. H. A Jalil
    ;
    Muhammad Firdaus Abdul Muttalib
    ;
    Fahisal Abdullah
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Shahidah Arina Shamsuddin
    ;
    Nursakinah Abdul Karim
    ;
    Ahmad Radi Wan Yaakub
    ;
    Nur Hulwani Ibrahim
    ;
    Tijjani Adam
    ;
    Nor Azizah Parmin
    ;
    Nadiya Akmal Baharum
    This study focuses on the encapsulation of silica and graphene nanoparticles and their potential applications. The encapsulation enhances the properties and effectiveness of these nanoparticles, with silica providing stability and graphene contributing to high surface area and electrical conductivity. Characterization of silica-graphene nanoparticles was conducted using various techniques including High Power Microscope (HPM), Scanning Electron Microscope (SEM), Energy-dispersive X-ray spectroscopy (EDS), and 3D Nano Profiler. The antimicrobial activity of silica, graphene, and silica-graphene nanoparticles was evaluated using a disc diffusion assay against E. coli and B. subtilis at varying concentrations. Results showed significant antimicrobial activity, with the inhibition zone being directly proportional to the concentration. Silica-graphene nanoparticles demonstrated higher efficacy against E. coli compared to B. subtilis, attributed to differences in cell wall structure. Statistical analysis using ANOVA confirmed significant differences in antimicrobial activity among the tested components.
  • Publication
    Revisiting the optoelectronic properties of graphene : a DFT approach
    ( 2024-01)
    L.O Agbolade
    ;
    Alaa Kamal Yousif Dafhalla
    ;
    A.Wesam Al-Mufti
    ;
    Zainal Abidin Arsat
    ;
    Tijjani Adam
    ;
    Abdullah Chik
    ;
    Subash Chandra Bose Gopinath
    ;
    Muhammad Nur Aiman Uda
    ;
    Uda Hashim
    Understanding the atomic behaviour of pure graphene is crucial in manipulating its properties for achieving optoelectronics with high absorption indexes and efficiencies. However, previous research employing the DFT approach emphasised its zero-band gap nature, not its unique optical properties. Therefore, this study employed ab initio calculations to revisit the electronic, magnetic, and optical properties of pristine graphene using the WIEN2K code. The results reveal that the PBE-GGA valence and conduction bands cross at -0.7 eV. Our calculations demonstrated that the absorption coefficient of graphene has the strongest light penetration in the parallel direction. Furthermore, our results not only present the best possible propagation of light in pure graphene but also reveal that the linear relationship between the formation of the free electron carriers and the energy absorption is responsible for the high optical conductivity observed in pure graphene, as indicated by the peaks. Lastly, the metallic properties of graphene are reflected by the variation in spin up and down that appears, as evidenced by the total and partial densities of states, and the large refractive index attributed to its high electron mobility confirms its metallic nature.
  • Publication
    Gold nanogap impedimetric biosensor for precise and selective Ganoderma boninense detection
    ( 2022-11-01)
    Dhahi T.S.
    ;
    Tijjani Adam
    ;
    Subash Chandra Bose Gopinath
    ;
    Uda Hashim
    Ganoderma species are common wood-rotting fungi that cause root and stem rot in most monocots, dicots, and gymnosperms. It influences plantation crops such as oil palm and rubber in Malaysia, but the effects vary greatly within the genus. Because of the complex chemistry of Ganoderma, extracting and identifying the physiologically active chemicals is often time-consuming and necessitates extensive bioassays. This study investigated the specific identification of the most infectious Ganoderma species using a sub-20-nm gold electrode. Three electrodes were created using chemically controlled etching (2, 10, and 20 nm). An AutoCAD mask containing nanogap pad electrodes was used to create a chrome glass surface, which was then translated and built. Following the successful construction of the device, the sensor was evaluated using a combination of conventional photolithography and a size reduction technique to imprint the nanogap design onto the gold surface. Ganoderma boninense target DNA was synthesised and surface-modified to enable interaction at extremely low molecular concentrations. The proposed device has a detection limit of 0.001 mol/L, which is seven times lower than the detection limits of currently available devices. The capacitance, conductivity, and permittivity of complementary, non-complementary, single mismatched, and targeted biomolecules changed during hybridization. This sensor correctly differentiated between all samples. The sensor's performance is further validated by comparing experimental data from the sensor to theoretical data from the sensor's corresponding circuit model. The two data sets are very similar.
      3
  • Publication
    An Update on Parkinson’s Disease and its Neurodegenerative Counterparts
    ( 2024-01-01)
    Adam H.
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohd Khairuddin Md Arshad
    ;
    Tijjani Adam
    ;
    Subramaniam S.
    ;
    Uda Hashim
    Introduction: Neurodegenerative disorders are a group of diseases that cause nerve cell degeneration in the brain, resulting in a variety of symptoms and are not treatable with drugs. Parkinson's disease (PD), prion disease, motor neuron disease (MND), Huntington's disease (HD), spinal cerebral dyskinesia (SCA), spinal muscle atrophy (SMA), multiple system atrophy, Alzheimer's disease (AD), spinocerebellar ataxia (SCA) (ALS), pantothenate kinase-related neurodegeneration, and TDP-43 protein disorder are examples of neurodegenerative diseases. Dementia is caused by the loss of brain and spinal cord nerve cells in neurodegenerative diseases. Background: Even though environmental and genetic predispositions have also been involved in the process, redox metal abuse plays a crucial role in neurodegeneration since the preponderance of symptoms originates from abnormal metal metabolism. Methods: Hence, this review investigates several neurodegenerative diseases that may occur symptoms similar to Parkinson's disease to understand the differences and similarities between Parkinson's disease and other neurodegenerative disorders based on reviewing previously published papers. Results: Based on the findings, the aggregation of alpha-synuclein occurs in Parkinson’s disease, multiple system atrophy, and dementia with Lewy bodies. Other neurodegenerative diseases occur with different protein aggregation or mutations. Conclusion: We can conclude that Parkinson's disease, Multiple system atrophy, and Dementia with Lewy bodies are closely related. Therefore, researchers must distinguish among the three diseases to avoid misdiagnosis of Multiple System Atrophy and Dementia with Lewy bodies with Parkinson's disease symptoms.
      4
  • Publication
    Integration of microfluidic channel on electrochemical-based nanobiosensors for monoplex and multiplex analyses: An overview
    ( 2023-05-01)
    Adam H.
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohd Khairuddin Md Arshad
    ;
    Tijjani Adam
    ;
    Uda Hashim
    ;
    Zaliman Sauli
    ;
    Fakhri M.A.
    ;
    Subramaniam S.
    ;
    Chen Y.
    ;
    Sasidharan S.
    ;
    Wu Y.S.
    Background: Microfluidic devices have evolved into low-cost, simple, and powerful analytical tool platforms. Herein, an electrochemically-based microfluidic nanobiosensor array for monoplex and multiplex detection of physiologically relevant analytes is reviewed. Unlike other analyte detection methods, microfluidics-based embedded electrochemical nanobiosensors are portable, custom electrochemical readers for signal reading. Methods: Microfluidic devices and electrochemical sensors can be integrated into monoplex or multiplex systems. The integrated system is simple to use and sensitive, and so has great potential as a powerful tool for profiling immune-mediated treatment responses in real time. It may also be developed further as a point-of-care diagnostic device for conducting near-patient tests using biological samples. Therefore, using mutiplex analysis, a biosensor array may detect multiple analytes in a sample solution and provide different outputs for each analyte. A microfluidic electrochemical nanobiosensor, for example, can detect urine glucose, lactate, and uric acid. The microfluidic array of integrated nanobiosensors and electrochemical sensors enables fast and cost-effective selection of high-quality and statistically significant diagnostic data at the point of care. The multiplex analytical test is an important molecular tool for academic research as well as clinical diagnosis. Although key approaches for analysing numerous analytes have been developed, none of them are suitable for point-of-care diagnostics, especially in situations with limited resources. Significant findings: In this study, monoplex and multiplex microfluidic assays for rapid measurement of single and multiple analytes at the point of care are presented. Since this test can analyse both single and multiple analytes, it is exceptionally specific, easy to use, and inexpensive. The ability of integrated electrochemical-based microfluidic devices with single channel and multiple channels systems to perform monoplex and multiplex analysis simultaneously and independently is the novelty of this review.
      4