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  5. Molecular-imprinting assisted polydopamine-aptasensor on carbon and gold nanomaterials construct for the haemophilia B biomarker detection
 
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Molecular-imprinting assisted polydopamine-aptasensor on carbon and gold nanomaterials construct for the haemophilia B biomarker detection

Journal
International Journal of Nanoelectronics and Materials (IJNeaM)
ISSN
1985-5761
Date Issued
2024-06
Author(s)
Hemavathi Krishnan
Universiti Malaysia Perlis
Subash Chandra Bose Gopinath
Universiti Malaysia Perlis
Tijjani Adam
Universiti Malaysia Perlis
Makram A. Fakhri
University of Technology-Iraq
Evan T. Salim
University of Technology-Iraq
Narendra Patil
Dr. A.P.J. Abdul Kalam University, India
Abstract
The study presents a comprehensive approach for enhancing the performance of a spiral micro-interdigitated electrode (spiral-μIDE) sensor for the detection of FIX protein. Electropolymerization using dopamine resulted in a molecular-imprinted polymer (polyDOP-μIDE-MIP) layer, which encapsulated the aptamer-FIX complex and was later leached to create cavities. Cyclic and linear-sweep voltammetry techniques were utilized for the MIP development and rebinding assessment. Linear sweep voltammetry demonstrated a linear relationship between FIX concentration and peak current reduction, with a limit of detection (LOD) of 0.250 picomolar. The sensor's sensitivity was determined as 2.613E-10 A.fM-1.μm-2. This work highlights the importance of nanomaterials integration, and electropolymerization in improving sensor performance. The integration of carbon and gold nanomaterials and the use of molecular imprinting contribute to the sensor's enhanced sensitivity and selective detection of FIX protein.
Subjects
  • Aptasensor

  • Molecularly imprinted...

  • Nanomaterials

  • Protein-MIP

  • Polydopamine

File(s)
Molecular-Imprinting Assisted Polydopamine-Aptasensor On Carbon and Gold Nanomaterials Construct for The Haemophilia B Biomarker Detection.pdf (498.27 KB)
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