Muhammad Nur Aiman Uda
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Preferred name
Muhammad Nur Aiman Uda
Official Name
Muhammad Nur Aiman, Uda
Alternative Name
Uda, M. N.A.
Aiman Uda, Muhammad Nur
Uda, M. N.A.
Main Affiliation
Scopus Author ID
55984680000
Researcher ID
V-7751-2019

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  • Publication
    Preliminary studies on antimicrobial activity of extracts from aloe vera leaf, citrus hystrix leaf, zingiber officinale and Sabah snake grass against bacillus subtilis
    ( 2018)
    Muhammad Nur Aiman Uda
    ;
    Subash Chandra Bose Gopinath
    ;
    Nur Hulwani Ibrahim
    ;
    Mohd Khairul Rabani Hashim
    ;
    Nuradibah Mohd Amer
    ;
    Midhat Nabil Ahmad Salimi
    ;
    Tan Ewe Shen
    ;
    Ong Yee Fen
    ;
    Maisara Azad Mat Akhir
    ;
    Uda Hashim
    Herbal plants have several potential antimicrobial activities either as antifungal or antibacterial to fight against the disease and pathogen that attack the plants. The extractions of the Aloe vera leaf, Citrus hystrix leaf, Zingiber officinale rhizome and Sabah snake grass were selected in this study to fight against Bacillus subtilis. B. subtilis is a Gram-positive bacterium, rodshaped and catalase-positive that lives on decayed organic material. It is known as Gram-positive bacteria because of its thick peptidoglycan and would appear purple when subjected to Gram test. This species is commonly found in the upper layers of the soil, in meat or vegetables, in pastry, cooked meat, in bread or poultry products. The extracts of Sabah Snake Grass found to be most effective than A.vera leaf, Z. officinale, and C. hystrix against the B. subtilis.
  • Publication
    Production and characterization of graphene from carbonaceous rice straw by cost-effect extraction
    ( 2021-05-01)
    Muhammad Nur Aiman Uda
    ;
    Subash Chandra Bose Gopinath
    ;
    Uda Hashim
    ;
    Halim N.H.
    ;
    Nor Azizah Parmin
    ;
    Muhammad Nur Afnan Uda
    ;
    Anbu P.
    This paper describes the synthesis of graphene-based activated carbon from carbonaceous rice straw fly ash in an electrical furnace and the subsequent potassium hydroxide extraction. The produced graphene has a proper morphological structure; flakes and a rough surface can be observed. The average size of the graphene was defined as up to 2000 nm and clarification was provided by high-resolution microscopes (FESEM and FETEM). Crystallinity was confirmed by surface area electron diffraction. The chemical bonding from the graphene was clearly observed, with –C=C– and O–H stretching at peaks of 1644 cm−1 and 3435 cm−1, respectively. Impurities in the graphene were found using X-ray photoelectron spectroscopy and energy dispersive X-ray spectroscopy. The measured size, according to zeta-potential analysis, was 8722.2 ± 25 nm, and the average polydispersity index was 0.576. The stability of the mass reduction was analyzed by a thermogravimetric at 100 Â°C, with a final reduction of ~ 11%.
  • Publication
    Voltammetric DNA Biosensor for Human Papillomavirus (HPV) Strain 18 Detection
    ( 2020-07-09)
    Mhd Akhir M.A.
    ;
    Nor Azizah Parmin
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Muhammad Nur Aiman Uda
    ;
    Muhammad Nur Afnan Uda
    ;
    Voon Chun Hong
    This research was developed to focus on the study of the voltammetric DNA biosensor for the detection of HPV strain 18. In this research, electrical DNA biosensor was expected to detect HPV strain 18 more efficiently by using electrical characterization. In this project, device inspection was conducted to make sure the functional of the gold interdigitated electrode (IDE) by using Scanning Electron Microscope (SEM). 3-Aminopropyl Triethoxysilane (APTES) solution was used for the process of surface modification to form the amine group on the surface of the device to facilitate the attachment of the DNA probe. In this project, synthetic DNA sample and DNA from the saliva of several Biosystems Engineering students were used as the target DNA. The current-voltage (I-V) electrical characterization was conducted to detect the presence of HPV strain 18 in both DNA samples. As the results, perfect alignment between the electrodes on the IDE was detected under SEM. Surface modification of the biosensor successfully conducted which is the covalent bond between APTES and DNA probe increase the electrical. Synthetic DNA shows the presence of HPV strain 18 while there was no HPV strain 18 detected in the DNA from saliva samples.
  • Publication
    Biosensor diagnostic system for selective detection of RNA Covid-19
    ( 2024-03-21)
    Muhammad Nur Aiman Uda
    ;
    Uda Hashim
    ;
    Muhd Nur Afnan Uda
    An outbreak of severe acute respiratory coronavirus 2 (SARS-CoV-2) infection occurred in Wuhan, Hubei Province, China and spread across China and beyond. WHO officially named the disease caused by the novel coronavirus as Coronavirus Disease 2019 (Covid-19). Features included pyrexia, radiological signs or acute respiratory distress, reduced or normal white blood cells, lymphopenia, and failure to resolve over 3 to 5 days of antibiotic treatment. This paper describes ultra-selective and rapid to detect the electrical signal generated by the biosensor that converts the biological reaction into an electrical signal and can make early RNA Covid-19 detection. As a step in preparing the biosensor, silanization with (3-Aminopropyl) Triethoxysilane (APTES), immobilization of RNA Covid-19 Probe were used. Then, the biosensor was hybridized to perform selectivity measurement using complementary and non-complementary RNA Covid-19 target.
  • Publication
    Distinct Detection of Ganoderma Boninense On Metal Oxides-Gold Nanoparticle Composite Deposited Interdigitated Electrode DNA sensor
    ( 2021-12-14)
    Thivina V.
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Adilah Ayoib
    ;
    Nordin N.K.S.
    ;
    Muhammad Nur Aiman Uda
    ;
    Muhammad Nur Afnan Uda
    Oil palms suffer severe losses due to Ganoderma boninense infection that causes Basal Stem Rot (BSR). The available detection measuring the severity of BSR disease have not proved satisfactory output. Due to the influence of oil palm industry in country's economy, effective and efficient means of diagnostic measure is mandatory. Among the available diagnostic tools, biosensors were redeemed to yield the most rapid and selective results. To overcome the current issues, herein Interdigitated Electrode (IDE) electrochemical DNA biosensor to detect Ganoderma boninense was successfully designed and fabricated by thermal deposition. Lift-off photolithography fabrication process was applied followed by the surface chemical functionalization via seed deposition. Zinc Oxide (ZnO) and Titanium Dioxide (TiO2) were overlaid and the functionalized metal oxides IDE surfaces were used to detect DNA sequence complementation from Ganoderma boninense. Furthermore, gold nanoparticles were doped to increase the surface to volume ratio and enhance biocompatibility. Characterizations were made by validating the sensor's topology characteristics and electrical characteristics. From the results recorded, it has been justified that IDE with ZnO doped with gold nanoparticles surface serves as an excellent DNA sensor for the detection of Ganoderma boninense with a remarkable current of 290 nA and 176 nA for immobilization and hybridization respectively.
  • Publication
    Analysis on silica and graphene nanomaterials obtained from rice straw for antimicrobial potential
    ( 2024-06)
    Muhammad Nur Aiman Uda
    ;
    N. H. A Jalil
    ;
    Muhammad Firdaus Abdul Muttalib
    ;
    Fahisal Abdullah
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Shahidah Arina Shamsuddin
    ;
    Nursakinah Abdul Karim
    ;
    Ahmad Radi Wan Yaakub
    ;
    Nur Hulwani Ibrahim
    ;
    Tijjani Adam
    ;
    Nor Azizah Parmin
    ;
    Nadiya Akmal Baharum
    This study focuses on the encapsulation of silica and graphene nanoparticles and their potential applications. The encapsulation enhances the properties and effectiveness of these nanoparticles, with silica providing stability and graphene contributing to high surface area and electrical conductivity. Characterization of silica-graphene nanoparticles was conducted using various techniques including High Power Microscope (HPM), Scanning Electron Microscope (SEM), Energy-dispersive X-ray spectroscopy (EDS), and 3D Nano Profiler. The antimicrobial activity of silica, graphene, and silica-graphene nanoparticles was evaluated using a disc diffusion assay against E. coli and B. subtilis at varying concentrations. Results showed significant antimicrobial activity, with the inhibition zone being directly proportional to the concentration. Silica-graphene nanoparticles demonstrated higher efficacy against E. coli compared to B. subtilis, attributed to differences in cell wall structure. Statistical analysis using ANOVA confirmed significant differences in antimicrobial activity among the tested components.
  • Publication
    Preliminary assessment for DNA extraction on microfluidic channel
    ( 2017-03-13)
    Subash Chandra Bose Gopinath
    ;
    Uda Hashim
    ;
    Muhammad Nur Aiman Uda
    The aim of this research is to extract, purify and yield DNA in mushroom from solid state mushroom sample by using fabricated continuous high-capacity sample delivery microfluidic through integrated solid state extraction based amino-coated silica bead. This device is made to specifically extract DNA in mushroom sample in continuous inflow process with energy and cost consumption. In this project, we present two methods of DNA extraction and purification which are by using centrifuge (complex and conventional method) and by using microfluidic biosensor (new and fast method). DNA extracted can be determined by using ultraviolet-visible spectroscopy (UV-VIS). The peak obtained at wavelength 260nm after measuring the absorbance of sample proves that DNA is successfully extracted from the mushroom.
  • Publication
    Facile electrical DNA genosensor for human papillomavirus (HPV 58) for early detection of cervical cancer
    ( 2023-07)
    F. Nadhirah Jaapar
    ;
    Nor Azizah Parmin
    ;
    Nur Hamidah Abdul Halim
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Ruslinda A. Rahim
    ;
    Sh. Nadzirah
    ;
    Voon Chun Hong
    ;
    Muhammad Nur Aiman Uda
    ;
    Wei Chern Ang
    ;
    Iffah Izzati Zakaria
    ;
    Zulida Rejali
    ;
    Amilia Afzan
    ;
    Azrul Azlan Hamzah
    ;
    Chang Fu Dee
    ;
    F. Syakirah Halim
    For decades, a Pap smear test has been applied as a conventional method in detecting Human Papillomavirus caused cervical cancer. False-positive results were also recorded while using it as conventional method. Current biosensor such as Hybrid (II) Capture resulted in higher time consumption and cost. s Meanwhile, in this study we provided facile, mini, rapid, highly sensitive, eco-friendly, and cost-effective sensing system focusing on HPV strain 58 (HPV58) in a nano-size lab-on-chip technology genosensor. 30-mer of virus ssDNA designed and analyzed as a probe via bioinformatics tools such as GenBank, Basic Local Alignment Searching Tools (BLAST) and ClustalW. Nanotechnology-developed colloidal Gold-nanoparticles (AuNPs) are used in the biosensor fabrication to produce high stability and electron efficient transmission during electrical measurement. AuNPs-APTES modified on active sites of IDEs, followed by immobilization of specific probe ssDNA for HPV 58. Hydrogen binding during hybridization with its target produce electrical signals measured by KEITHLEY 2450 (Source Meter). The genosensor validated with different types of targets such as complimentary, non-complementary and single mismatch oligonucleotides. The serial dilution of target concentration has been experimented triplicate (n=3) range from 1fM to 10μM. The slope of calibration curve resulted 2.389E-0 AM-1 with regression coefficient (R2) = 0.97535.
  • Publication
    Facile Electrical DNA Genosensor for Human Papillomavirus (HPV 58) for Early Detection of Cervical Cancer
    ( 2023-07-01)
    Jaapar F.N.
    ;
    Nor Azizah Parmin
    ;
    Halim N.H.A.
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Ruslinda A. Rahim
    ;
    Nadzirah S.
    ;
    Voon Chun Hong
    ;
    Muhammad Nur Aiman Uda
    ;
    Ang W.C.
    ;
    Zakaria I.I.
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Hamzah A.A.
    ;
    Dee C.F.
    ;
    Halim F.S.
    For decades, a Pap smear test has been applied as a conventional method in detecting Human Papillomavirus caused cervical cancer. False-positive results were also recorded while using it as conventional method. Current biosensor such as Hybrid (II) Capture resulted in higher time consumption and cost. s Meanwhile, in this study we provided facile, mini, rapid, highly sensitive, eco-friendly, and cost-effective sensing system focusing on HPV strain 58 (HPV58) in a nano-size lab-on-chip technology genosensor. 30-mer of virus ssDNA designed and analyzed as a probe via bioinformatics tools such as GenBank, Basic Local Alignment Searching Tools (BLAST) and ClustalW. Nanotechnology-developed colloidal Gold-nanoparticles (AuNPs) are used in the biosensor fabrication to produce high stability and electron efficient transmission during electrical measurement. AuNPs-APTES modified on active sites of IDEs, followed by immobilization of specific probe ssDNA for HPV 58. Hydrogen binding during hybridization with its target produce electrical signals measured by KEITHLEY 2450 (Source Meter). The genosensor validated with different types of targets such as complimentary, non-complementary and single mismatch oligonucleotides. The serial dilution of target concentration has been experimented triplicate (n=3) range from 1fM to 10µM. The slope of calibration curve resulted 2.389E-0 AM-1 with regression coefficient (R2) = 0.97535.
  • Publication
    Risk factor analysis for stunting incidence using sparse categorical principal component logistic regression
    (Elsevier, 2025-01)
    Anna Islamiyati
    ;
    Muhammad Nur Aiman Uda
    ;
    Abdul Salam
    ;
    Dwi Auliyah
    ;
    Wan Zuki Azman Wan Muhamad
    The risk factors for stunting incidence involve categorical data in both the response and predictor variables. Therefore, we developed a sparse categorical principal component logistic regression model capable of handling data with multicollinearity. The parameters of the sparse categorical principal component logistic regression model were estimated using the maximum likelihood method and the Newton-Raphson iterative approach. The analysis yielded a likelihood ratio value of 144.81 and a chi-square statistic value of 11.07, indicating that all factors included in the model are statistically significant. The results highlight that medical history, inadequate complementary feeding, formula feeding, lack of complementary feeding programs, and lack of iron supplementation for mothers are highly associated with the risk of stunting in toddlers. This emphasizes the need for attention to maternal nutrition from pregnancy through breastfeeding, as well as the nutrition of the toddler. Some important points proposed in this method are: • Stunting data consists of categorical variables containing multicollinearity. • The method applied is sparse logistic regression combined with categorical principal component analysis. • Analysis of risk factors for stunting in toddlers is based on the child's own condition, as well as parental factors, namely age, education, and intake of additional food and supplementary tablets during pregnancy.