Muhammad Nur Aiman Uda
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Preferred name
Muhammad Nur Aiman Uda
Official Name
Muhammad Nur Aiman, Uda
Alternative Name
Uda, M. N.A.
Aiman Uda, Muhammad Nur
Uda, M. N.A.
Main Affiliation
Scopus Author ID
55984680000
Researcher ID
V-7751-2019

Research Output

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  • Publication
    Gold-nanoparticle associated deep eutectic solution mediates early bio detection of ovarian cancer
    ( 2025-01)
    S. Uvambighai Devi
    ;
    Nor Azizah Parmin
    ;
    N. Fareezah Jaapar
    ;
    F. Syakirah Halim
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Muhammad Nur Aiman Uda
    ;
    Voon Chun Hong
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Adilah Ayoib
    ;
    Shahidah Arina Shamsuddin
    ;
    Norizah Abd Karim
    Gold nanoparticles (AuNPs) have indeed been extensively researched in biological and photothermal therapy applications in recent years. This study aims to enhance the sensitivity of biosensors for early detection of ovarian cancer biomarkers by investigating the efficacy of DES-mediated surface functionalization of AuNPs. Additionally, the impact of DES on the stability and dispersion of AuNPs on SiO2 support is assessed to optimize sensor performance. A simple DES-mediated synthesis method for efficient amine surface functionalization of silicon dioxide (SiO2) to incorporate tiny AuNPs for antibody biosensors. Physical characterization [Scanning Electron Microscope (SEM), Ultraviolet-Visible Spectrophotometer (UV-Vis), Fourier Transform Infrared Spectroscopy (FTIR), and 3D Profiler] and electrical characterization (Keithley) have been done to determine the functionalization of the modified IDE surface. SEM analysis indicated the resultant nanoparticles have truncated spherical shapes. There is just a peak recorded by UV-Vis at 504-540 nm with AuNPs due to the formation of monodispersed AuNPs. When the conjugation of DES with samples is measured, the curves are identical in form, and the highest peak after conjugation has remained at 230 nm but the SPR absorption peak becomes narrower and moves toward greater wavelengths, indicating the conjugation between the molecules. Furthermore, when the DES is conjugated with AuNPs, 3-Aminopropyltriethoxysilane (APTES), antibody, and protein, the peaks gradually increased and became narrower, where O-H at 3280 cm-1, C-H at 2809 cm-1 and 2933 cm-1, CH2 at 1448 cm-1, CH3 at 1268 cm-1, C-OH at 1048 cm-1 and 1110 cm-1 and C-N+ at 844 cm-1 as analyzed by FTIR. Moreover, it can be observed that the 3D profilometer revealed a few red-colored areas, which are the portion that protrudes from the IDE surface. Based on the findings, it is possible to infer that this immunosensor does have the prospective to be used in clinical investigations for the precise detection of ovarian cancer or other biomarkers. The capacitance, transmittance, and resistivity profiles of the biosensor clearly distinguished between the antibody immobilization and the affinity binding. The presence of a DES-mediated synthetic approach increased the possibility of supporting different metal nanoparticles on SiO2 as the potential platform for biosensor applications.
  • Publication
    Aluminium interdigitated electrode with 5.0 μm gap for electrolytic scooting
    ( 2024-06)
    Uda Hashim
    ;
    Muhammad Nur Aiman Uda
    ;
    Tijjani Adam
    ;
    Asral Bahari Jambek
    ;
    Ismail Saad
    ;
    Nor Azizah Parmin
    ;
    Shahidah Arina Shamsuddin
    ;
    Nursakinah Abdul Karim
    ;
    G. Yashni
    ;
    Nur Hulwani Ibrahim
    ;
    N. Parimon
    ;
    M. F. H. Rani
    The goal of the research project is to design, fabricate, and characterize an extremely sensitive biosensor for use in healthcare. Using AutoCAD software, a novel IDE pattern with a 5 μm finger gap was created. Conventional photolithography and regular CMOS technology were used in the fabrication process. A 3D nano profiler, scanning electron microscopy (SEM), high-power microscopy (HPM), and low-power microscopy (LPM) were used to physically characterize the manufactured IDE. Chemical testing was done using several pH buffer solutions, and electrical validation was performed using I-V measurements. The Al IDE was produced, with a tolerance of 0.1 μm between the fabricated IDEs and the design mask. Electrical measurements verified the flawless fabrication of the IDE, and the device's repeatability was validated by the outcomes of comparable IDE samples. For each pH buffer solution, a modest additional volume of 2 μl was used to quantitatively detect slight current fluctuations in the microampere range. Through pH calibration for advanced applications in the realm of chemical sensors using an amperometric method, this research study has verified the chemical behavior of the IDE.