Yufridin Wahab
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Preferred name
Yufridin Wahab
Official Name
Yufridin, Wahab
Alternative Name
Wahab, Yufridin
Wahab, Y.
Wahab, Y. Abdul
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Scopus Author ID
6507764452
Researcher ID
P-8844-2014

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  • Publication
    A Numerical Study of Collective Cell Migration in a Microchannel Driven by Surface Acoustic Wave (SAW) Device
    ( 2023-01-01)
    Mazlee Mazalan
    ;
    Anas Mohd Noor
    ;
    Yufridin Wahab
    ;
    Shazlina Johari
    ;
    Mohd Rosydi Zakaria
    ;
    Zaman W.S.W.K.
    Collective cell migration is involved in a variety of biological contexts, including tissue morphogenesis, wound healing, and cancer invasion. Many studies have revealed that chemical, mechanical, and electrical stimulation all affect cell migration. Although an acoustic stimulus has been shown to influence cell migration in the past, the underlying mechanism is still unknown. A computational model that accounts for acoustic-structure interaction was constructed in this study to simulate the formation of a surface acoustic wave (SAW) field and the application of the acoustic pressure field on collective cell migration. A group of cells within a microchannel device and two ports of interdigitated transducers (IDTs) with different wavelengths were modeled. The stresses within cells were investigated as it was influenced by substrate displacement and pressure acoustic in the cell media generated by the SAW device. As a result, we observed the local stress within cells near the solid-fluid interfaces. For propagating SAW, the shorter wavelength of IDTs (600 μm) attributed to high stress at the cell's top and bottom as compared to the SAW device with the longer wavelength (1000 μm). The standing SAW occurred underneath collective cells. The results of standing SAW on cell stress at the bottom confirm that the SAW device can be useful to regulate the abnormalities cellular activities associated with cell migration.
      5  31
  • Publication
    Characterization of Excimer Laser Micromachining Parameters to Derive Optimal Performance for the Production of Polydimethylsiloxane (PDMS)-based Microfluidic Devices
    ( 2024-01-01)
    Shazlina Johari
    ;
    Ting Z.K.
    ;
    Mazlee Mazalan
    ;
    Yufridin Wahab
    ;
    Anas Mohd Noor
    ;
    Mohd Fairus Ahmad
    ;
    Muhammad Mahyiddin Ramli
    Laser micromachining has been used as an alternative to producing microfluidics structures and simplifying the conventional soft lithography process. In this paper we characterize the excimer laser micromachining parameters and demonstrate its application by producing several microfluidic structures in polydimethylsiloxane (PDMS). The parameters include the number of laser pulses, laser energy and rectangular variable aperture (RVA) in both x- and y-directions. We found that the laser energy and pulse rate affect the depth of micromachining d channels, while RVA in both x- and y-directions affects the width of the channels. Repetition of laser scan does not change the channel width but significantly changes the channel depth. Proper adjustment for laser energy and pulse rate is required to fabricate a desired channels depth. In order to demonstrate the microfabrication capability of an excimer laser with the optimal operating parameters, several microfluidic structures were micromachining d into PDMS with a KrF excimer laser.
      1
  • Publication
    Numerical Simulation of Transdermal Iontophoretic Drug Delivery System
    ( 2021-11-25)
    Anas Mohd Noor
    ;
    Zulkarnay Zakaria
    ;
    Shazlina Johari
    ;
    Norhayati Sabani
    ;
    Yufridin Wahab
    ;
    Manaf A.A.
    Transdermal Iontophoretic Drug Delivery System (TIDDS) is a non-invasive method of systemic drug delivery that involves by applying a drug formulation to the skin. The drug penetrates through the stratum corneum, epidermis and dermis layers. Once the drug reaches the dermal layer, it is available for systemic absorption via dermal microcirculation. However, clinical testing of new drug developed for the iontophoretic system is a long and complex process. Recently, most of those major pharmaceutical companies have attempted to consider computer-based bio-simulation strategies as a means of generating the data necessary to help make a better decision. In this work, we used computational modelling to investigate the TIDDS behaviour. Our interest is to study the efficacy of drug diffusion through transdermal delivery, including the thermal effect on the skin. We found that drug will be delivered more efficiently if the electrical potential and the position of electrodes are optimum. We analysed the drug diffusion time of the system using 1,3 and 5 mA DC source. In addition, we also modify the electrode distance from 10 mm to 30 mm long and analysed the effect of delivery time and d effect to the skin thermal. We conclude that, a high electrical current, as instance, a 5 mA DC, delivered the drug faster into the skin but increased the skin temperature because of skin joule heating effect. However, a 30 mm electrodes distance setting decreased the skin temperature significantly than the 10 mm distance with more than 9.7 °C under 5 mA DC and 60 minutes of operation. TIDDS enhanced drug delivery compared to oral consumption and might be suitable used for localizing treatments such as chronic disease. This work provides great potential and is useful to efficiently design of iontophoretic drug delivery system including new drugs delivery applications.
      1  36