Voon Chun Hong
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Preferred name
Voon Chun Hong
Official Name
Hong, Voon Chun
Alternative Name
Voon, C. H.
Voon, Chun Hong
Hong, Voon Chun
Hong, V. C.
Main Affiliation
Scopus Author ID
55334719400
Researcher ID
D-2050-2015

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  • Publication
    Voltammetric DNA Biosensor for Human Papillomavirus (HPV) Strain 18 Detection
    ( 2020-07-09)
    Mhd Akhir M.A.
    ;
    Nor Azizah Parmin
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Muhammad Nur Aiman Uda
    ;
    Muhammad Nur Afnan Uda
    ;
    Voon Chun Hong
    This research was developed to focus on the study of the voltammetric DNA biosensor for the detection of HPV strain 18. In this research, electrical DNA biosensor was expected to detect HPV strain 18 more efficiently by using electrical characterization. In this project, device inspection was conducted to make sure the functional of the gold interdigitated electrode (IDE) by using Scanning Electron Microscope (SEM). 3-Aminopropyl Triethoxysilane (APTES) solution was used for the process of surface modification to form the amine group on the surface of the device to facilitate the attachment of the DNA probe. In this project, synthetic DNA sample and DNA from the saliva of several Biosystems Engineering students were used as the target DNA. The current-voltage (I-V) electrical characterization was conducted to detect the presence of HPV strain 18 in both DNA samples. As the results, perfect alignment between the electrodes on the IDE was detected under SEM. Surface modification of the biosensor successfully conducted which is the covalent bond between APTES and DNA probe increase the electrical. Synthetic DNA shows the presence of HPV strain 18 while there was no HPV strain 18 detected in the DNA from saliva samples.
  • Publication
    Facile electrical DNA genosensor for human papillomavirus (HPV 58) for early detection of cervical cancer
    ( 2023-07)
    F. Nadhirah Jaapar
    ;
    Nor Azizah Parmin
    ;
    Nur Hamidah Abdul Halim
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Ruslinda A. Rahim
    ;
    Sh. Nadzirah
    ;
    Voon Chun Hong
    ;
    Muhammad Nur Aiman Uda
    ;
    Wei Chern Ang
    ;
    Iffah Izzati Zakaria
    ;
    Zulida Rejali
    ;
    Amilia Afzan
    ;
    Azrul Azlan Hamzah
    ;
    Chang Fu Dee
    ;
    F. Syakirah Halim
    For decades, a Pap smear test has been applied as a conventional method in detecting Human Papillomavirus caused cervical cancer. False-positive results were also recorded while using it as conventional method. Current biosensor such as Hybrid (II) Capture resulted in higher time consumption and cost. s Meanwhile, in this study we provided facile, mini, rapid, highly sensitive, eco-friendly, and cost-effective sensing system focusing on HPV strain 58 (HPV58) in a nano-size lab-on-chip technology genosensor. 30-mer of virus ssDNA designed and analyzed as a probe via bioinformatics tools such as GenBank, Basic Local Alignment Searching Tools (BLAST) and ClustalW. Nanotechnology-developed colloidal Gold-nanoparticles (AuNPs) are used in the biosensor fabrication to produce high stability and electron efficient transmission during electrical measurement. AuNPs-APTES modified on active sites of IDEs, followed by immobilization of specific probe ssDNA for HPV 58. Hydrogen binding during hybridization with its target produce electrical signals measured by KEITHLEY 2450 (Source Meter). The genosensor validated with different types of targets such as complimentary, non-complementary and single mismatch oligonucleotides. The serial dilution of target concentration has been experimented triplicate (n=3) range from 1fM to 10μM. The slope of calibration curve resulted 2.389E-0 AM-1 with regression coefficient (R2) = 0.97535.
  • Publication
    Facile Electrical DNA Genosensor for Human Papillomavirus (HPV 58) for Early Detection of Cervical Cancer
    ( 2023-07-01)
    Jaapar F.N.
    ;
    Nor Azizah Parmin
    ;
    Halim N.H.A.
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Ruslinda A. Rahim
    ;
    Nadzirah S.
    ;
    Voon Chun Hong
    ;
    Muhammad Nur Aiman Uda
    ;
    Ang W.C.
    ;
    Zakaria I.I.
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Hamzah A.A.
    ;
    Dee C.F.
    ;
    Halim F.S.
    For decades, a Pap smear test has been applied as a conventional method in detecting Human Papillomavirus caused cervical cancer. False-positive results were also recorded while using it as conventional method. Current biosensor such as Hybrid (II) Capture resulted in higher time consumption and cost. s Meanwhile, in this study we provided facile, mini, rapid, highly sensitive, eco-friendly, and cost-effective sensing system focusing on HPV strain 58 (HPV58) in a nano-size lab-on-chip technology genosensor. 30-mer of virus ssDNA designed and analyzed as a probe via bioinformatics tools such as GenBank, Basic Local Alignment Searching Tools (BLAST) and ClustalW. Nanotechnology-developed colloidal Gold-nanoparticles (AuNPs) are used in the biosensor fabrication to produce high stability and electron efficient transmission during electrical measurement. AuNPs-APTES modified on active sites of IDEs, followed by immobilization of specific probe ssDNA for HPV 58. Hydrogen binding during hybridization with its target produce electrical signals measured by KEITHLEY 2450 (Source Meter). The genosensor validated with different types of targets such as complimentary, non-complementary and single mismatch oligonucleotides. The serial dilution of target concentration has been experimented triplicate (n=3) range from 1fM to 10µM. The slope of calibration curve resulted 2.389E-0 AM-1 with regression coefficient (R2) = 0.97535.
  • Publication
    Microwave welding with SiCNW/PMMA nanocomposite thin films: enhanced joint strength and performance
    (Institute of Physic, 2025-01)
    Phey Yee Foong
    ;
    Voon Chun Hong
    ;
    Lim Bee Ying
    ;
    Foo Wah Low
    ;
    Teh Pei Leng
    ;
    Nor Azizah Parmin
    ;
    Subash Chandra Bose Gopinath
    ;
    Veeradasan Perumal
    ;
    Yeoh Cheow Keat
    ;
    Nor Azura Abdul Rahim
    Most previously reported susceptors for microwave welding are in powder form. In this study, a thin-film susceptor was employed due to its uniform heating rate and ease of handling. Silicon carbide nanowhisker (SiCNW) were incorporated into a poly(methyl methacrylate) (PMMA) matrix to create a nanocomposite thin film, which served as the susceptor. The microwave welding process involved three straightforward steps: fabrication of the PMMA/SiCNW nanocomposite thin film, application of the nanocomposite film to the target area, and subsequent microwave heating. Upon cooling, a robust microwave-welded joint was formed. The mechanical properties and microstructure of the welded joints were characterized using single-lap shear tests, three-point bending tests, and scanning electron microscopy. Results demonstrated that the shear strength and elastic modulus of the welded joints were optimized with increased heating time and SiCNW filler loading. This optimization is attributed to the formation of a SiCNW-filled polypropylene (PP) nanocomposite layer of increasing thickness at the welded joint interface. However, the incorporation of SiCNW also constrained the mobility of the PP chains, reducing the joint’s flexibility. Furthermore, the welded joint formed with the PMMA/SiCNW nanocomposite thin-film susceptor exhibited an 18.82% improvement in shear strength compared to joints formed with a powdered SiCNW susceptor. This study not only demonstrates the potential of PMMA/SiCNW nanocomposite thin films as efficient susceptors for microwave welding but also paves the way for developing high-performance polymer-based composite joints with improved mechanical properties for applications in the automotive, aerospace, and construction industries.
  • Publication
    Designing DNA probe from human Papillomavirus (HPV) 58 in E6 region as biosensing element for development of biosensor
    ( 2024-03-21)
    Jaapar N.F.
    ;
    Nor Azizah Parmin
    ;
    Halim N.H.A.
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Ruslinda A. Rahim
    ;
    Nadzirah S.
    ;
    Voon Chun Hong
    ;
    Muhammad Nur Aiman Uda
    ;
    Ang W.C.
    ;
    Zakaria I.I.
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Hamzah A.A.
    ;
    Dee C.F.
    ;
    Halim F.S.
    Globally, second leading cause of death for women is a Cervical Cancer. CC is caused by infection of Human Papillomavirus (HPV). HPV strains 16 (50.8%), 18 (17.6%), and 58 (2.6%) became the most leading strains of infection in Malaysia. Recently, a study showed that HPV 58 was rare worldwide but famous in Asia countries including Malaysia. However, detection the significance of HPV-58 in women has not been studied extensively because of rare case compared to HPV 16 and 18. HPV-58 is commonly found in East Asia, but infrequently worldwide, due to changes in the environment of viruses and humans. Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the HPV. The oligonucleotide sequences of HPV 58 in E6 region have been analysed between 24-35 mer in order to maintain the specificity and selectivity. The percentage of similarities between the coding sequences has developed with 66.7% of GC content. The DNA probe of HPV 58 was 5'GGG CGC TGT GCA GTG TGT TGG AGA CCC CGA3' with 30 mer of oligonucleotides. The important of E6 region for developing the coding sequence as it involved in the DNA reproduction, transcription, translation regulation and transformation of HPV genome. Phylogenetic trees were then constructed by Neighbour-Joining and the Kimura 2-parameters methods, followed by an analysis of selection pressures acting on the E6/E7 genes by ebi ac uk tools.
      20  2
  • Publication
    Potentials of MicroRNA in Early Detection of Ovarian Cancer by Analytical Electrical Biosensors
    ( 2022-01-01)
    Nor Azizah Parmin
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Nadzirah S.
    ;
    Salimi M.N.
    ;
    Voon Chun Hong
    ;
    Muhammad Nur Aiman Uda
    ;
    Muhammad Nur Afnan Uda
    ;
    Rozi S.K.M.
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Azan M.I.A.
    ;
    Yaakub A.R.W.
    ;
    Hamzah A.A.
    ;
    Dee C.F.
    The importance of nanotechnology in medical applications especially with biomedical sensing devices is undoubted. Several medical diagnostics have been developed by taking the advantage of nanomaterials, especially with electrical biosensors. Biosensors have been predominantly used for the quantification of different clinical biomarkers toward detection, screening, and follow-up the treatment. At present, ovarian cancer is one of the severe complications that cannot be identified until it becomes most dangerous as the advanced stage. Based on the American Cancer Society, 20% of cases involved in the detection of ovarian cancer are diagnosed at an early stage and 80% diagnosed at the later stages. The patient just has a common digestive problem and stomach ache as early symptoms and people used to ignore these symptoms. Micro ribonucleic acid (miRNA) is classified as small non-coding RNAs, their expressions change due to the association of cancer development and progression. This article reviews and discusses on the currently available strategies for the early detection of ovarian cancers using miRNA as a biomarker associated with electrical biosensors. A unique miRNA-based biomarker detections are specially highlighted with biosensor platforms to diagnose ovarian cancer.
      1  43
  • Publication
    Formation of polypropylene nanocomposite joint using silicon carbide nanowhiskers as novel susceptor for microwave welding
    ( 2023-05-01)
    Foong P.Y.
    ;
    Voon Chun Hong
    ;
    Lim B.Y.
    ;
    Teh P.L.
    ;
    Mohd Afendi Rojan
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohd Khairuddin Md Arshad
    ;
    Nor Azizah Parmin
    ;
    Low F.W.
    ;
    Ruslinda A. Rahim
    ;
    Uda Hashim
    Up to present, no study has reported on the use of silicon carbide nanomaterials (SiCNMs) as susceptor for microwave welding of thermoplastics. Therefore, in this study, silicon carbide nanowhiskers (SiCNWs) was attempted as the microwave susceptor for the microwave welding of polypropylene (PP). It was observed that SiCNWs are capable of absorbing microwave and converting them into heat, leading to a sharp increase in temperature until it reaches the melting point of PP substrates. The microwave welded joint is formed after the molten PP at the interface between PP substrates is cooled under pressure. The effect of microwave heating duration and solid loading of SiCNWs suspension was studied and reported. The formation mechanism of SiCNWs reinforced PP welded joint was proposed in this study. With these remarkable advantages of microwave welding and enhanced mechanical properties of the welded joint, it is believed that this study can provide a new insight into welding of thermoplastic and material processing through short-term microwave heating.
      26  1
  • Publication
    Microwave welding of thermoplastic using silicon carbide nanowhiskers as susceptor effect of heating duration
    ( 2024-06)
    Phey Yee Foong
    ;
    Voon Chun Hong
    ;
    Lim Bee Ying
    ;
    Teh Pei Leng
    ;
    Yeoh Cheow Keat
    ;
    Mohd Afendi Rojan
    ;
    Nor Azizah Parmin
    ;
    Subash Chandra Bose Gopinath
    ;
    Foo Wah Low
    ;
    Muhammad Kashif
    ;
    Nor Azura Abdul Rahman
    ;
    Sam Sung Ting
    ;
    Veeradasan Perumal
    Microwave welding is becoming more popular than conventional joining methods due to its advantages such as rapid and localised heating as well as applicable to components with complicated geometry. Previously reported susceptor, such as carbonaceous materials and conductive polymers, are toxic and the welding process involving these susceptors is time-consuming. Because of its exceptional microwave absorption and biocompatibility, silicon carbide nanowhiskers (SiCNWs) was employed as the microwave susceptor for microwave welding. Microwave welding in this study comprises of only three simple steps: SiCNWs suspension preparation, SiCNWs application and microwave heating. The weld strength of welded joint was then characterised using tensile test and energy dispersive x-ray spectroscopy equipped scanning electron microscopy (EDS-SEM) to study its mechanical properties and cross-section microstructure. The influence of microwave irradiation time was studied in this study, and it is found that the weld strength rose with the extension of microwave irradiation time, until a maximum weld strength of 1.61 MPa was achieved by 17 s welded joint. The development of SiCNWs reinforced PP nanocomposite welded joint layer is responsible for the enhanced weld strength. Prolonged heating duration may also result in flaws such as void formation at the welded joint, which subsequently lowered the weld strength to 0.60 MPa when the heating duration was extended to 20 s. In sum, a strengthen welded joint can be formed with rapid microwave heating under the proper control of heating duration.
      10  54
  • Publication
    Microwave Welding of Thermoplastic using Silicon Carbide Nanowhiskers as Susceptor: Effect of Heating Duration
    ( 2024-06-01)
    Foong P.Y.
    ;
    Voon Chun Hong
    ;
    Lim Bee Ying
    ;
    Teh Pei Leng
    ;
    Yeoh Cheow Keat
    ;
    Mohd Afendi Rojan
    ;
    Nor Azizah Parmin
    ;
    Low F.W.
    ;
    Subash Chandra Bose Gopinath
    ;
    Kashif M.
    ;
    Rahman N.A.A.
    ;
    Sam Sung Ting
    ;
    Perumal V.
    Microwave welding is becoming more popular than conventional joining methods due to its advantages such as rapid and localised heating as well as applicable to components with complicated geometry. Previously reported susceptor, such as carbonaceous materials and conductive polymers, are toxic and the welding process involving these susceptors is time-consuming. Because of its exceptional microwave absorption and biocompatibility, silicon carbide nanowhiskers (SiCNWs) was employed as the microwave susceptor for microwave welding. Microwave welding in this study comprises of only three simple steps: SiCNWs suspension preparation, SiCNWs application and microwave heating. The weld strength of welded joint was then characterised using tensile test and energy dispersive x-ray spectroscopy equipped scanning electron microscopy (EDS-SEM) to study its mechanical properties and cross-section microstructure. The influence of microwave irradiation time was studied in this study, and it is found that the weld strength rose with the extension of microwave irradiation time, until a maximum weld strength of 1.61 MPa was achieved by 17 s welded joint. The development of SiCNWs reinforced PP nanocomposite welded joint layer is responsible for the enhanced weld strength. Prolonged heating duration may also result in flaws such as void formation at the welded joint, which subsequently lowered the weld strength to 0.60 MPa when the heating duration was extended to 20 s. In sum, a strengthen welded joint can be formed with rapid microwave heating under the proper control of heating duration.
      1  23
  • Publication
    Dielectric properties and microwave absorbing properties of silicon carbide nanoparticles and silicon carbide nanowhiskers
    ( 2023-04)
    Phey Yee Foong
    ;
    Voon Chun Hong
    ;
    Lim Bee Ying
    ;
    Teh Pei Leng
    ;
    Mohd Afendi Rojan
    ;
    Subash Chandra Bose Gopinath
    ;
    Nor Azizah Parmin
    ;
    Mohd Khairuddin Md Arshad
    ;
    Yeng Seng Lee
    ;
    Ruslinda A. Rahim
    ;
    Uda Hashim
    Silicon carbide (SiC) is well known for their outstanding microwave absorbing properties. SiC nanomaterials (SiCNMs) are expected to have better microwave absorption performance due to their high specific surface area. To date, no study was reported to compare the dielectric properties and microwave absorbing properties of different type of SiCNMs. Therefore, the objective of this paper is to compare the dielectric properties and microwave absorption properties of different types of SiCNMs. In this paper, SiC nanoparticles (SiCNPs) and SiC nanowhiskers (SiCNWs) were characterised using SEM and XRD. In addition, their dielectric properties and microwave absorbing properties were measured using network analyser and transmission line theory. It was found that SiCNWs achieved higher dielectric constant and loss factor which are and εr’ =17.94 and εr″ = 2.64 compared to SiCNPs that only achieved εr’ = 2.83 and εr″ = 0.71. For microwave absorbing properties, SiCNWs and SiCNPs attained minimum reflection loss of -10.41 dB and -6.83 dB at 5.68 GHz and 17.68 GHz, respectively. The minimum reflection loss of SiCNPs and SiCNWs obtained in this study is much lower than the nanometer-SiC reported previously. These results suggested that SiCNWs can be an ideal candidate of microwave susceptors for various microwave applications
      1  13