Uda Hashim
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Preferred name
Uda Hashim
Official Name
Uda, Hashim
Alternative Name
Hashimb, U.
Hashim, Uda
Hashim, U.
Uda, Hashim
Main Affiliation
Scopus Author ID
22633937800
Researcher ID
CVC-6955-2022

Research Output

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Now showing 1 - 10 of 42
  • Publication
    Potential of Syntesized Silica Nanoparticles (Si-NPs) using Corn Cob for Arsenic Heavy Metal Removal
    ( 2020-07-09)
    Balasubramaniam T.
    ;
    Bakar A.H.A.
    ;
    Muhammad Nur Aiman Uda
    ;
    Uda Hashim
    ;
    Parmin N.A.
    ;
    Anuar A.
    ;
    Bakar M.A.A.
    ;
    Muhammad Nur Afnan Uda
    ;
    Sulaiman M.K.
    According to recent studies, millions of people are suffering from Arsenic (As) toxicity contamination. Arsenic is one of the most toxic and carcinogenic chemical elements and its contamination in paddy field has become a chronic problem. In the agricultural sector, arsenic-contaminated water irrigation has a higher level of arsenic contamination on the top soil, which can affect the quality of crop production such as rice plants. Rice plant requires a considerable amount of water to complete its lifecycle. In Asean countries like Malaysia, Indonesia and Thailand, Arsenic intake from rice is significantly higher, as rice plants have a special ability to take up arsenic from the soil and water used for irrigation. The transfer of arsenic from soil to plant systems is a serious issue that leads to considerable human exposure. Nanotechnology application plays vital role for any field work and research. In this research, the implementation of nanotechnology approach such as silica nanoparticles are able to remove the Arsenic heavy metal contamination. This paper focused on arsenic heavy metal removal using silica nanoparticles analaysed using spectrophotometric method.
  • Publication
    Characterization of Genome Sequence 2019 Novel Coronavirus (2019-nCoV) by using BioinformaticTool
    ( 2020-07-09)
    Parmin N.A.
    ;
    Uda Hashim
    ;
    Hamidah A Halim N.
    ;
    Muhammad Nur Aiman Uda
    ;
    Muhammad Nur Afnan Uda
    A novel coronavirus (2019-nCoV) became the seventh member in the family of Coronavirus that infect human. 2019-nCoV became the most severe virus compare to another family of coronavirus. Human airway ephitelial cells have been used to identify and isolate the virus before proceed to reverse trancriptase Polymerase Chain Reaction (RT-PCR). Detailed biological knowledge is crucial for the development of effective countermeasures, diagnostic tests, vaccines and antiviral drugs against the 2019-nCoV. Conserved coding sequences within the spike glycoprotein region of open reading frame in the coronavirus genome was used as the basis to design oligonucleotide probe to detect the virus. Analyses on different strain of coronavirus sequences were done to check the percentage of similarity and consensus region that cause different strain of viruses. The biomarker needed an acceptable length between 22 and 31 mers. The choice of S gene region was identified and can be used as a biomarker probe for biosensor development. It has implications for coronavirus detection techniques in clinical and biosensor diagnostic system.
  • Publication
    Voltammetric DNA Biosensor for Human Papillomavirus (HPV) Strain 18 Detection
    ( 2020-07-09)
    Mhd Akhir M.A.
    ;
    Nor Azizah Parmin
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Muhammad Nur Aiman Uda
    ;
    Muhammad Nur Afnan Uda
    ;
    Voon Chun Hong
    This research was developed to focus on the study of the voltammetric DNA biosensor for the detection of HPV strain 18. In this research, electrical DNA biosensor was expected to detect HPV strain 18 more efficiently by using electrical characterization. In this project, device inspection was conducted to make sure the functional of the gold interdigitated electrode (IDE) by using Scanning Electron Microscope (SEM). 3-Aminopropyl Triethoxysilane (APTES) solution was used for the process of surface modification to form the amine group on the surface of the device to facilitate the attachment of the DNA probe. In this project, synthetic DNA sample and DNA from the saliva of several Biosystems Engineering students were used as the target DNA. The current-voltage (I-V) electrical characterization was conducted to detect the presence of HPV strain 18 in both DNA samples. As the results, perfect alignment between the electrodes on the IDE was detected under SEM. Surface modification of the biosensor successfully conducted which is the covalent bond between APTES and DNA probe increase the electrical. Synthetic DNA shows the presence of HPV strain 18 while there was no HPV strain 18 detected in the DNA from saliva samples.
  • Publication
    Gold Nanoparticles Enhanced Electrochemical Impedance Sensor (EIS) for Human Papillomavirus (HPV) 16 Detection E6 region
    ( 2020-07-09)
    Amrul Muhadi A.S.
    ;
    Nor Azizah Parmin
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Muhammad Nur Afnan Uda
    ;
    Muhammad Nur Aiman Uda
    ;
    Hong V.C.
    The persistent infection by high risk HPV is a necessary but not sufficient cause of this cancer which develops over a long period through precursor lesions which can be detected by electrochemical impedance sensor. The HPV driven molecular mechanisms underlying the development of cervical lesions have provided a number of potential biomarkers for both diagnostic and prognostic use in the clinical management of women with HPV related cervical disease and these biomarkers can also be used to increase the positive predictive value of current methods. The most influential methods for the detection and identification of HPV using gold nanoparticle (GNP) included electrochemical impedance sensor will visit their sensitivity, selectivity and characteristic detection on synthetic target which are complement of the DNA, non-complement of the DNA and mismatch of the DNA. In difference concentration of synthetic target, which stage can get the exactly value to determine the HPV in strain 16 was evaluated in this research studies.
  • Publication
    Designing DNA probe from HPV 18 and 58 in the E6 region for sensing element in the development of genosensor-based gold nanoparticles
    ( 2022-10-01)
    Jaapar F.N.
    ;
    Nor Azizah Parmin
    ;
    Nur Hamidah Abdul Halim
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Halim F.S.
    ;
    Ruslinda A. Rahim
    ;
    Voon Chun Hong
    ;
    Muhammad Nur Aiman Uda
    ;
    Muhammad Nur Afnan Uda
    ;
    Nadzirah S.
    ;
    Rejali Z.
    ;
    Afzan A.
    ;
    Zakaria I.I.
    The E6 region has higher protuberant probability annealing than consensus probe focusing on another region in the human papillomavirus (HPV) genome in terms of detection and screening method. Here, we designed the first multiple virus single-stranded deoxyribonucleic acid (ssDNA) for multiple detections in an early phase of screening for cervical cancer in the E6 region and became a fundamental evolution of detection electrochemical HPV biosensor. Gene profiling of the virus ssDNA sequences has been carried by high-end bioinformatics tools such as GenBank, Basic Local Alignment Searching Tools (BLAST), and Clustal OMEGA in a row. The output from bioinformatics tools resulted in 100% of similarities between our virus ssDNA probe and HPV complete genome in the databases. The cross-validation between HPV genome and our designed virus ssDNA provided high specificity and selectivity during screening methods compared with Pap smear. The DNA probe for HPV 18, 5′ COOH-GAT CCA GAA GGT ACA GAC GGG GAG GGC ACG 3′, while 5′COOH-GGG CGC TGT GCA GTG TGT TGG AGA CCC CGA3′ as DNA probe for HPV 58 designed with 66.77% guanine (G) and cytosine (C) content for both. Our virus ssDNA probe for the HPV biosensor promises high sensitivity, specificity, selectivity, repeatability, low fluid consumption, and will be useful in mini-size diagnostic devices for cervical cancer detection.
  • Publication
    Development of Internet of Things (IOT) Based Electronic Reader for Medical Diagnostic System
    ( 2020-03-18)
    Muhammad Nur Afnan Uda
    ;
    Asral Bahari Jambek
    ;
    Uda Hashim
    ;
    Muhammad Nur Aiman Uda
    ;
    Bahrin M.A.F.
    This paper is about an experiment for performing foodborne pathogens electronic reader using wireless sensing Internet of Thing (IoT). There are limited number of electronic readers for biosensors application with wireless internet connection. This research is to overcome the problem of commercial available electronic reader based on biosensor application method that only can be perform in offline or standalone device. This paper shows a complete system on how the data from electronic reader can be collected, easily understand by user and transfer data through the wireless internet connection via platform of IoT. There are three stages that is coding modification, android application development and transmit data to cloud storage. The NodeMCU microcontroller was used as a transfer medium for transfer data to internet. The Android Studio software was used for mobile application development. While, Arduino software was used to create a programming code to upload in NodeMCU microcontroller.
  • Publication
    New Development Quantification Methods for Salt Iodine and Urinary Iodine Using Microfluidics Based Nanotechnology
    ( 2020-03-18)
    Nur Hulwani Ibrahim
    ;
    Midhat Nabil Ahmad Salimi
    ;
    Muhammad Nur Aiman Uda
    ;
    Nor Azizah Parmin
    ;
    Uda Hashim
    ;
    Muhammad Nur Afnan Uda
    In Malaysia, the first Iodine Deficiency Disorders (IDD) survey was conducted in 1996 and it was discovered that Peninsular Malaysia did not have IDD problem until latter studies showed goitre occurrence of 34.7% in Hulu Langat district and urinary iodine lower than the adequate level of (100-199 ug/L) in Perak and Pahang states (Selamat et al., 2010). Baseline and periodical sampling of children and pregnant woman urine and imported salt commodities for the consumption of the population is mandatory for iodine measurement. Thus, development of quantitative methods of measurement of salt and food iodine is crucial for implementation of the USI program nationwide. In this study, interdigitated electrode (IDE) biosensor, a rapid, sensitive and selective method has been developed to determine the iodine content in both urine and salt. This method includes functionalization and silanization step using 3-aminopropyl triethoxysilane (APTES). The I-V characterization of IDE biosensor was performed using (Keithley 2450), Kickstart software and Probestation. It measures the amount of current flow through IDE which is directly proportional to the concentration of iodine in both urine and salt. Hence, IDE biosensor is proven to be a rapid, selective, sensitive method and can be developed as a new nanotechnology for the elimination of Iodine Deficiency Disorders (IDD) among children and pregnant woman.
  • Publication
    Green route synthesis of antimicrobial nanoparticles using sewage alga bloom
    ( 2023-01-01)
    H.M A.
    ;
    Muhammad Nur Afnan Uda
    ;
    Subash Chandra Bose Gopinath
    ;
    Arsat Z.A.
    ;
    Abdullah F.
    ;
    Muttalib M.F.A.
    ;
    Hashim M.K.R.
    ;
    Uda Hashim
    ;
    Muhammad Nur Aiman Uda
    ;
    Yaakub A.R.W.
    ;
    Ibrahim N.H.
    ;
    Parmin N.A.
    ;
    Tijjani Adam
    Nanoparticles have a large surface area for their size and interact effectively with other particles. AgNPs may be created chemically, physically, or biologically. Biological techniques are considered the safest and cleanest since they use no toxic chemicals. Biological synthesis involves plant extracts, bacteria, fungus, algae, and other organisms. The algal production of AgNPs is of major interest. The abundance of algae and the ease with which it can be grown in a lab are two of the many reasons why it has become so popular as a nanoparticle production source. In this study, algae were employed as nanoparticles and antibacterial inhibitors against microbes.
      2
  • Publication
    Integrated ZnO-Al2O3 nano particles as absorbent for heavy metal ions and organic impurities
    ( 2021-05-03)
    Tijjani Adam
    ;
    Uda Hashim
    ;
    Mohan Mugguntan
    ;
    Muhammad Nur Afnan Uda
    ;
    Muhammad Nur Aiman Uda
    Nanotechnology is an emerging interdisciplinary technology that has been booming in many areas during recent decade. The objective of this work was to verify Activated Alumina for removal of heavy metal arsenic with designed filtration unit. Alumina and Zinc oxide nanoparticles were successfully synthesized using both sol-gel and chemical techniques. This study is mainly focused on the synthesis method of Al2O3-NPs using two different type of acids namely sulphuric acid and hydrochloric acid with the base NaOH and KOH. The water treatment filtration unit designed using AutoCAD software. The alumina is prepared to remove heavy metals, especially arsenic from drinking water in order to obtain clean water. Chemical synthesis method of ZnO-NPs was carried out using prepared sodium hydroxide and zinc nitrate heptahydrate zinc acetate. The samples were characterized by different techniques such as Fourier transform infrared spectra (FTIR) and UV-vis. The average crystallite size of synthesized alumina range from 7.1 to 28 nm.
      4
  • Publication
    MPTES decorated IDE for arsenic (AS) selective detection
    ( 2021-05-03)
    Muhammad Nur Aiman Uda
    ;
    Tijjani Adam
    ;
    Mosbah A.B.
    ;
    Uda Hashim
    ;
    Muhammad Nur Afnan Uda
    Heavy metals ions are ions which generally occupied most part water sources such river, sea and other water flow channels such as drainage, water pipe. The exist of the ions in drinking water traces have called the attention researchers due to the recent discovery of the ions problem in both human health and aquatic animal such as fish. Fish come and encounter heavy metals ions in the river and ingest it and subsequently this fish eaten by man. The ions will pass to human and attack some human orgains. Finding the reliable solution to detect traces of heavy metals ions in water is a promising approach to eliminate such problems. This research aim is to enhance detection of heavy sensors, for sensor technology industry using the fabricated MTES surface-modified silicon interdigitated electrode to detect arsenic ion in water, The device was fabricated using conventional photolithography process coupled with deep RIE etching. The fabricated devices was modified surface and characterized by Scanning Electron Microscopy, Atomic Force Microscopy and high-power microscopy. The electrical analysis by applying voltage to measure the device response to the surface modification step and subsequently against arsenic ion as it bonded to the device via MPTES, various MTES concentrations distinguished against the bare device and arsenic concentration. Based on current and voltage analysis, concentration-dependent results were obtained, the detection limit for surface modified IDE to the arsenic detection was 20 pM with the linear response behaviour to the concentration, Thus, with this wonderful detection limits, the devices high high-performance characteristic by selectively distinguish arsenic ions against other foreign elements in the water.
      7