Nur Hamidah Abdul Halim
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Preferred name
Nur Hamidah Abdul Halim
Official Name
Nur Hamidah, Abdul Halim
Alternative Name
Halim, Nur Hamidah Abdul
Halim, N. H.A.
Hamidah A Halim, N.
Halim, N. H.
Halim, N. Hamidah A.
Abdul Halim, Nur Hamidah
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Scopus Author ID
55493444600

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  • Publication
    Micro-interdigitated electrodes genosensor based on Au-deposited nanoparticles for early detection of cervical cancer
    ( 2023-12-31)
    Jaapar F. Nadhirah
    ;
    Nor Azizah Parmin
    ;
    Nur Hamidah Abdul Halim
    ;
    Uda Hashim
    ;
    Subash Chandra Bose Gopinath
    ;
    Fatin Syakirah Halim
    ;
    Muhammad Nur Aiman Uda
    ;
    Amilia Afzan
    ;
    Noorhashimah Mohamad Nor
    ;
    Khairunisak Abdul Razak
    Genosensor-based electrodes mediated with nanoparticles (NPs) have tremendously developed in medical diagnosis. Herein, we report a facile, rapid, low cost and highly sensitive biosensing strategy for early detection of HPV 18 using gold-nanoparticles (AuNPs) deposited on micro-IDEs. This study represents surface charge transduction of micro-interdigitated electrodes (micro-IDE) alumina insulated with silica, independent and mini genosensor modified with colloidal gold NPs (AuNPs), and determination of gene hybridization for early detection of cervical cancer. The surface of AuNPs deposited micro-IDE functionalized with optimized 3-aminopropyl-triethoxysilane (APTES) followed by hybridization with deoxyribonucleic acid (DNA) virus to develop DNA genosensor. The results of ssDNA hybridization with the ssDNA target of human papillomavirus (HPV) 18 have affirmed that micro-IDE functionalized with colloidal AuNPs resulted in the lowest detection at 0.529 aM. Based on coefficient regression, micro-IDE functionalized with AuNPs produces better results in the sensitivity test (R2 = 0.99793) than unfunctionalized micro-IDE.
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