Mazlee Mazalan
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Preferred name
Mazlee Mazalan
Official Name
Mazlee, Mazalan
Alternative Name
Mazalan, Mazlee Bin
Mazalan, Mazlee
Main Affiliation
Scopus Author ID
54420543000
Researcher ID
FKZ-3093-2022

Research Output
Now showing 1 - 2 of 2
  • Publication
    A Numerical Study of Collective Cell Migration in a Microchannel Driven by Surface Acoustic Wave (SAW) Device
    ( 2023-01-01)
    Mazlee Mazalan
    ;
    Anas Mohd Noor
    ;
    Yufridin Wahab
    ;
    Shazlina Johari
    ;
    Mohd Rosydi Zakaria
    ;
    Zaman W.S.W.K.
    Collective cell migration is involved in a variety of biological contexts, including tissue morphogenesis, wound healing, and cancer invasion. Many studies have revealed that chemical, mechanical, and electrical stimulation all affect cell migration. Although an acoustic stimulus has been shown to influence cell migration in the past, the underlying mechanism is still unknown. A computational model that accounts for acoustic-structure interaction was constructed in this study to simulate the formation of a surface acoustic wave (SAW) field and the application of the acoustic pressure field on collective cell migration. A group of cells within a microchannel device and two ports of interdigitated transducers (IDTs) with different wavelengths were modeled. The stresses within cells were investigated as it was influenced by substrate displacement and pressure acoustic in the cell media generated by the SAW device. As a result, we observed the local stress within cells near the solid-fluid interfaces. For propagating SAW, the shorter wavelength of IDTs (600 μm) attributed to high stress at the cell's top and bottom as compared to the SAW device with the longer wavelength (1000 μm). The standing SAW occurred underneath collective cells. The results of standing SAW on cell stress at the bottom confirm that the SAW device can be useful to regulate the abnormalities cellular activities associated with cell migration.
      1
  • Publication
    Characterization of Excimer Laser Micromachining Parameters to Derive Optimal Performance for the Production of Polydimethylsiloxane (PDMS)-based Microfluidic Devices
    ( 2024-01-01)
    Shazlina Johari
    ;
    Ting Z.K.
    ;
    Mazlee Mazalan
    ;
    Yufridin Wahab
    ;
    Anas Mohd Noor
    ;
    Mohd Fairus Ahmad
    ;
    Muhammad Mahyiddin Ramli
    Laser micromachining has been used as an alternative to producing microfluidics structures and simplifying the conventional soft lithography process. In this paper we characterize the excimer laser micromachining parameters and demonstrate its application by producing several microfluidic structures in polydimethylsiloxane (PDMS). The parameters include the number of laser pulses, laser energy and rectangular variable aperture (RVA) in both x- and y-directions. We found that the laser energy and pulse rate affect the depth of micromachining d channels, while RVA in both x- and y-directions affects the width of the channels. Repetition of laser scan does not change the channel width but significantly changes the channel depth. Proper adjustment for laser energy and pulse rate is required to fabricate a desired channels depth. In order to demonstrate the microfabrication capability of an excimer laser with the optimal operating parameters, several microfluidic structures were micromachining d into PDMS with a KrF excimer laser.
      1