Mohamed Elshaikh Elobaid Said Ahmed
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Preferred name
Mohamed Elshaikh Elobaid Said Ahmed
Official Name
Mohamed Elshaikh Elobaid , Said Ahmed
Alternative Name
Ahmed, Mohamed Elshaikh Elobaid Said
Said Ahmed, Mohamed Elshaikh Elobaid
Elobaid, Mohamed Elshaikh
Main Affiliation
Scopus Author ID
57190012447
Researcher ID
R-7502-2019

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  • Publication
    Application of Nanobiosensor engineering in the diagnosis of neurodegenerative disorders
    (Elsevier, 2024)
    Thikra S. Dhahi
    ;
    Alaa Kamal Yousif Dafhalla
    ;
    A. Wesam Al-Mufti
    ;
    Mohamed Elshaikh Elobaid Said Ahmed
    ;
    Tijjani Adam
    ;
    Subash Chandra Bose Gopinath
    Neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are hard to diagnose and treat early. They are characterised by progressive loss of neuronal function and structure leading to crippling cognitive, motor and psychiatric impairments. In recent years, nanobiosensor engineering has emerged as a promising way to address the limitations of traditional diagnostic methods for neurodegenerative diseases. Nanobiosensors which combine nanotechnology and biosensing principles can detect disease specific biomarkers with high sensitivity and specificity to enable early and accurate diagnosis. One of the key advantages of nanobiosensors in diagnosing neurodegenerative diseases is their ability to detect and quantify specific proteins or molecules that are biomarkers for these conditions. For example, accumulation of amyloid beta peptides and hyperphosphorylation of tau protein are hallmarks of Alzheimer's disease. Nanobiosensors can be designed to selectively bind to these biomarkers providing rapid and non-invasive method for early disease detection. This enables more targeted and personalized treatment approaches. Furthermore, nanomaterials have shown potential in biosensing applications due to their unique physical, optical, and electrical properties. Their small size, large surface-to-volume ratio, and tunable properties enable them to interact with biological molecules in remarkable ways. One notable property is their ability to be functionalized with molecular beacons, reporter molecules, pacification layers, and targeting biomolecules, creating highly sensitive and specific biofunctional nanoprobes. This review aims to explore the promising role of nanobiosensor engineering in the early diagnosis and management of neurodegenerative disorders.
  • Publication
    The importance, benefits, and future of nanobiosensors for infectious diseases
    ( 2024-04-01)
    Dhahi T.S.
    ;
    Dafhalla A.K.Y.
    ;
    Saad S.A.
    ;
    Zayan D.M.I.
    ;
    Ahmed A.E.T.
    ;
    Mohamed Elshaikh Elobaid Said Ahmed
    ;
    Tijjani Adam
    ;
    Subash Chandra Bose Gopinath
    Infectious diseases, caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi, are crucial for efficient disease management, reducing morbidity and mortality rates and controlling disease spread. Traditional laboratory-based diagnostic methods face challenges such as high costs, time consumption, and a lack of trained personnel in resource-poor settings. Diagnostic biosensors have gained momentum as a potential solution, offering advantages such as low cost, high sensitivity, ease of use, and portability. Nanobiosensors are a promising tool for detecting and diagnosing infectious diseases such as coronavirus disease, human immunodeficiency virus, and hepatitis. These sensors use nanostructured carbon nanotubes, graphene, and nanoparticles to detect specific biomarkers or pathogens. They operate through mechanisms like the lateral flow test platform, where a sample containing the biomarker or pathogen is applied to a test strip. If present, the sample binds to specific recognition probes on the strip, indicating a positive result. This binding event is visualized through a colored line. This review discusses the importance, benefits, and potential of nanobiosensors in detecting infectious diseases.
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