Mohamad Faris Mohamad Fathil
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Preferred name
Mohamad Faris Mohamad Fathil
Official Name
Mohamad Faris, Mohamad Fathil
Alternative Name
Fathil, Mohamad Faris Mohamad
Fathil, Mohamad Faris Bin Mohamad
Main Affiliation
Scopus Author ID
56395434600
Researcher ID
U-3213-2019

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  • Publication
    Impact of buried oxide thickness in substrate-gate integrated silicon nanowire field-effect transistor biosensor performance for charge sensing
    ( 2021-07-21)
    Tan Y.M.
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Norhayati Sabani
    ;
    Teoh X.Y.
    ;
    Mohd Khairuddin Md Arshad
    ;
    Subash Chandra Bose Gopinath
    ;
    Rahman S.F.A.
    ;
    Uda Hashim
    The paper investigated on performance in charge sensing for substrate-gate integrated silicon nanowire field-effect transistor biosensor at different thickness of the buried oxide layer, sandwiched in between the top-silicon and substrate layers. The device structures with different buried oxide thickness ranging from 100 to 200 nm were designed and simulated using the Silvaco ATLAS device simulation software. The increase of buried oxide thickness reduced the strength of induced electric field that contributes to the formation of inversion layer for current flow through the silicon nanowire channel, hence contributed to the increase in threshold voltage. For simulation of charge sensing, the device demonstrated the ability to identify different interface charge values ranging from -5×1010 to -9×1010 e· cm-2 applied on the surface of the silicon nanowire channel to represent target charge biomolecules that bound to the biosensor in actual detection. Significant change in threshold voltage can be observed due to the applied interface charge density values and was evaluated to determine the sensitivity for charge sensing performance. The device shows better performance when designed with buried oxide thickness of 200 nm at sensitivity of 1.151 V/e· cm-2.
  • Publication
    Impedimetric Lectin Biosensor for Prostate Cancer Detection
    ( 2021-01-01)
    Abd Rahman S.F.
    ;
    Mohd Khairuddin Md Arshad
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Sarry F.
    ;
    Md Nor M.N.
    There is considerable attention on the determination of prostate-specific antigen (PSA) glycosylation patterns for the early detection of prostate cancer, as it is one of the most reliable tumor biomarkers. In this study, the highly effective lectin-based biosensor utilizing gold interdigitated microelectrode was developed as a sensing transducer, coupled with electrochemical impedance spectroscopy (EIS) for the sensitive detection of biomolecules event on the device. The self-assembled monolayer using 11-mercaptoundecanoic acid was utilized to modify the sensor surface for the conjugation of Maackia amurensis lectin as biorecognition elements. The analytical analysis of the developed lectin biosensor with PSA glycosylation through impedimetric measurement exhibited a linear detection ranging from 100 pg/mL to 100 ng/mL and attained a detection limit of 27.6 pg/mL.
  • Publication
    Lectin bioreceptor approach in capacitive biosensor for prostate-specific membrane antigen detection in diagnosing prostate cancer
    ( 2021-03-01)
    Subramani I.G.
    ;
    Ramzan Mat Ayub
    ;
    Subash Chandra Bose Gopinath
    ;
    Perumal V.
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Mohd Khairuddin Md Arshad
    This research reports a new approach with lectin-based capacitive non-faradaic biosensor for the detection of prostate-specific membrane antigen (PSMA) as a promising diagnostic marker for determining prostate cancer. PSMA expression is significantly higher in malign hyperplasia, thus can be effectively employed to discriminate other benign prostatic diseases. Herein, the aluminium interdigitated electrode was fabricated and modified by a linker, 2-mercaptoacetate to form the self-assembled monolayer. Gold nanoparticles were used as a signal amplifier and supported the conjugation of Concanavalin A, for efficient capacitive sensing of PSMA. Scanning electron microscope observation effectively captured the surface modification on the aluminium surface by revealing the specific adherence of gold nanoparticles with Concanavalin A. Moreover, the successful surface modification was further validated by atomic force microscopy, Fourier transforms infrared spectroscopy, and X-ray photoelectron spectroscopy. The interaction analysis of Concanavalin A with PSMA by capacitive non-faradaic measurement exhibited a linear detection range from 10 pM to 100 nM and attained the detection limit and sensitivity of 10 pM and 1.65 nF/pM respectively as the comparable performance to the current sensing strategies. Furthermore, the fabrication and quantification of PSMA as demonstrated here are relatively simple and can be employed for the straightforward detection of other biomarkers.
  • Publication
    Design and simulation of Cylindrical Stacked Silicon Nanowire (SiNW) field-effect transistors
    (IEEE, 2023-12)
    H’ng Chee Chang
    ;
    Mohd Khairuddin Md Arshad
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Subash Chandra Bose Gopinath
    ;
    Ramzan Mat Ayub
    In continuous effort to increase the current drive without sacrificing the off current and better off gate control on the channel, the MOSFET devices have advanced from classical, planar, single-gate and three-dimensional devices with multi-gate structures. Recently, multi-bridge-channel technology has become a feasible solution beyond FinFET multi-gate structure. In this work, we design Gate-All-Around (GAA) based on silicon nanowire. Numerical simulation based Silvaco Device tools has been used to design multiple number of cylindrical nanowires, then followed by different channel diameter, consisting of 20, 30 and 40 nm. The devices are the characterized on transconductance, threshold voltage, DIBL and subthreshold slope. The simulation results indicate that the device performance is best at a nanowire diameter of 20 nm due to improved gate control over charge distribution. Regarding the number of nanowires, the voltage performance is not significantly affected by Nnw =1 or higher. However, higher numbers of nanowires, such as Nnw = 3, demonstrate improved drain current and transconductance.
  • Publication
    Immunosensing prostate-specific antigen: Faradaic vs non-Faradaic electrochemical impedance spectroscopy analysis on interdigitated microelectrode device
    ( 2020-11-01)
    Ibau, Conlathan
    ;
    Mohd Khairuddin Md Arshad
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Shahidah Arina Shamsuddin
    This work explores Electrochemical Impedance Spectroscopy (EIS) detection for a highly-sensitive quantification of prostate-specific antigen (PSA) in Faradaic (f-EIS) and non-Faradaic modes (nf-EIS). Immobilization of monoclonal antibody specific to PSA (anti-PSA) was performed using 1-ethyl-3-dimethylaminopropylcarbodiimide hydrochloride and N-hydroxysuccinimide crosslinking agents in order to conjugate carboxylic (-COOH) terminated group of 16-Mercaptoundecanoic acid with amine (-NH3+) on anti-PSA epitope. This approach offers simple and efficient approach to form a strong, covalently bound thiol-gold (S–Au) for a reliable SAM layer formation. Studies on the topographic of pristine Au-IDE surface were performed by Scanning Electron Microscopy and Energy Dispersive X-ray Spectroscopy techniques, meanwhile a 3-dimensional optical surface profiler, Atomic Force Microscopy and X-ray Photoelectron Spectroscopy techniques were used to validate the successful functionalization steps on the sensor transducer surface. Detection of PSA in f-EIS mode was carried out by measuring the response in charge transfer resistance (Rct) and impedance change (Z), meanwhile in nf-EIS mode, the changes in device capacitance was monitored. In f-EIS mode, the sensor reveals a logarithmic detection of PSA in a range of 100 ng/ml down to 0.01 ng/ml in Phosphate Buffered Saline with a recorded sensitivity of 2.412 kΩ/log10 ([PSA] ng/ml) and the limit of detection (LOD) down to 0.01 ng/ml. The nf-EIS detection mode yields a logarithmic detection range of 5000 ng/ml down to 0.5 ng/ml, with a sensitivity of 8.570 nF/log10 ([PSA] ng/ml) and an LOD of 0.5 ng/ml. The developed bio-assay yields great device stability, specificity to PSA and repeatability of detection that would pave its way for the future development into portable lab-on-chip bio-sensing system.
      10  27
  • Publication
    The impact of silicon nanowire transducer channel width on field-effect transistor biosensor performance
    ( 2021-05-03)
    Abdullah R.F.
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Mohd Khairuddin Md Arshad
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Subash Chandra Bose Gopinath
    ;
    Uda Hashim
    ;
    Ong C.C.
    ;
    Tamjis N.
    ;
    Ghazali M.H.M.
    This paper reported on performance assessment of a field-effect transistor-based biosensor with different widths of the silicon nanowire transducer channel. Silvaco ATLAS device simulation software was used to model the device design with three different channel widths, which are 100, 150, and 200 nm. In this simulation, the bounded target biomolecules during actual detection using the biosensor were represented by several negative interface charge density values applied on the surface of the transducer channel. Increase in accumulation of hole carriers beneath the channel's surface was observed due to the availability of negative interface charges on the surface, hence increased the output drain current. Furthermore, width reduction of the device's channel had allowed more significant change in drain current due to application of different interface charge density values and increased the device's sensitivity. Among the simulated devices, silicon nanowire field-effect transistor-based biosensor with transducer channel width of 100 nm had shown highest sensitivity (-56.45 nA/e.cm2) with lowest interface charge density detection (2.79u1010 e/cm-2), which means it enhances the interface charge detection by providing better response and allows lower limit of detection. Therefore, in actual detection, possibility for reaction of the transducer channel to the specific target biomolecule can be increased.
      1  19
  • Publication
    Impedimetric cardiac biomarker determination in serum mediated by epoxy and hydroxyl of reduced graphene oxide on gold array microelectrodes
    ( 2021-08-01)
    Steven Taniselass
    ;
    Mohd Khairuddin Md Arshad
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Ibau C.
    ;
    Anbu P.
    A label-free chemical bonding strategy mediated by reduced graphene oxide (rGO) basal plane functional groups has been developed for cardiac Troponin I (cTnI) detection. Four different chemical strategies on respective electrode sensing surface were precedingly examined using electrochemical impedance spectroscopy. The impedimetric assessment was carried out by sweeping frequency at the range 0.1–500 kHz perturbated at a small amplitude of AC voltage (25 mV). The chemical strategy-4 denoted as S-4 shows a significant analytical performance on cTnI detection in spiked buffer and human serum, whereby the pre-mixture of rGO and (3-Aminopropyl)triethoxysilane (APTES) creates a large number of amine sites (−NH2), which significantly enhanced the antibody immobilization without excessive functionalization. The as-fabricated immunosensor exhibited an ultra-low limit of detection of 6.3 ag mL−1 and the lowest antigen concentration measured was at 10 ag mL−1. The immunosensor showed a linear and wide range of cTnI detection (10 ag mL−1–100 ng mL−1) in human serum with a regression coefficient of 0.9716, rapid detection (5 min of binding time), and stable and highly reproducible bioelectrode response with RSD < 5%. Hence, the demonstrated S-4 strategy is highly recommended for other downstream biosensors applications. Graphical abstract: [Figure not available: see fulltext.].
      3  33
  • Publication
    Molybdenum disulfide—gold nanoparticle nanocomposite in field-effect transistor back-gate for enhanced C-reactive protein detection
    ( 2020-11-01)
    Dalila N.R.
    ;
    Mohd Khairuddin Md Arshad
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Mohamad Faris Mohamad Fathil
    Nanofabricated gold nanoparticles (Au-NPs) on MoS2 nanosheets (Au-NPs/MoS2) in back-gated field-effect transistor (BG-FET) are presented, which acts as an efficient semiconductor device for detecting a low concentration of C-reactive protein (C-RP). The decorated nanomaterials lead to an enhanced electron conduction layer on a 100-μm-sized transducing channel. The sensing surface was characterized by Raman spectroscopy, ultraviolet–visible spectroscopy (UV-Vis), atomic force microscopy (AFM), scanning electron microscopy (SEM), and high-power microscopy (HPM). The BG-FET device exhibits an excellent limit of detection of 8.38 fg/mL and a sensitivity of 176 nA/g·mL−1. The current study with Au-NPs/MoS2 BG-FET displays a new potential biosensing technology; especially for integration into complementary metal oxide (CMOS) technology for hand-held future device application. [Figure not available: see fulltext.]
      5  30
  • Publication
    Fabrication and characterization of aluminium interdigitated electrode hybrid with ZnO for cardiac troponin T biomarker detection
    (AIP Publishing, 2018-12-06)
    Letchumanan Iswary
    ;
    Nazri N.F.N.
    ;
    Mohd Khairuddin Md Arshad
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Subash Chandra Bose Gopinath
    This article describes the fabrication and characterization of the aluminum interdigitated electrode (IDE) hybrid with ZnO for the detection of cardiac troponin T (cTnT) biomarker. IDE was modified with one type of probe, which is antibody for troponin T (MAb-cTnT). Initially, it starts with the fabrication process including cleaning of the wafer and followed by a conventional lithography process. Then, surface modification using ZnO as a transducer, which is responsible for signal amplifier. Then, it followed by sensor characterization using atomic force microscope (AFM) and 3D Surface (Nano) Profilometer. Surface functionalization using 3-aminopropyltriethoxysilane (APTES) and glutaraldehyde was carried out. Next, the immobilization step was performed by adding antibody followed by antigen where the negative charges will accumulate on the surface of IDE. To evaluate the detection limit, different concentrations of antigen were applied independently from l0 to l00?ng/mL to detect the troponin T. I-V characterization was performed after each antigen concentration detection. The characterization of IDE was worked out using scanning electron microscope and atomic force microscope before and after the detection step. Here, detected the changes occurred when the attachment of different concentrations of an antigen using I-V characteristics.
      3  9
  • Publication
    Interdigitated impedimetric-based Maackia amurensis lectin biosensor for prostate cancer biomarker
    ( 2024-02-01)
    Rahman S.F.A.
    ;
    Mohd Khairuddin Md Arshad
    ;
    Subash Chandra Bose Gopinath
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Sarry F.
    ;
    Ibau C.
    ;
    Elmazria O.
    ;
    Hage-Ali S.
    Highly specific detection of tumor-associated biomarkers remains a challenge in the diagnosis of prostate cancer. In this research, Maackia amurensis (MAA) was used as a recognition element in the functionalization of an electrochemical impedance-spectroscopy biosensor without a label to identify cancer-associated aberrant glycosylation prostate-specific antigen (PSA). The lectin was immobilized on gold-interdigitated microelectrodes. Furthermore, the biosensor’s impedance response was used to assess the establishment of a complex binding between MAA and PSA-containing glycans. With a small sample volume, the functionalized interdigitated impedimetric-based (IIB) biosensor exhibited high sensitivity, rapid response, and repeatability. PSA glycoprotein detection was performed by measuring electron transfer resistance values within a concentration range 0.01–100 ng/mL, with a detection limit of 3.574 pg/mL. In this study, the ability of MAA to preferentially recognize α2,3-linked sialic acid in serum PSA was proven, suggesting a potential platform for the development of lectin-based, miniaturized, and cost effective IIB biosensors for future disease detection. Graphical Abstract: [Figure not available: see fulltext.].
      1  25