This research presented a perpendicular high isolation MIMO antenna for LTE advance application. A high gain perpendicular MIMO antenna is concentrated on designing used in LTE advance application. The issues of low isolation of conventional antenna can be solved by structuring a MIMO antenna in order to increase the isolation in LTE advance application. Generally, the array antenna design causes a bigger antenna size and has a mutual coupling which lead to spectral efficiency damage and reduce the MIMO antenna framework performance. The substrate material like FR-4 is choosing as a dielectric substrate due to its good performances for many applications beside it has a low cost and more usable. The advantage of copper such as has a great relative material, cheaper and easy to construct is choose in this project as a conductive material. ADS software has been utilized for the structure stage to design the antenna. Then, the results are evaluated in terms of return loss (S11 and S22), mutual coupling (S12 and S21), match impedance, directivity, radiation pattern, gain and radiated power. Vector Network Analyzer (VNA) is used to measure the fabricated antenna. The factor of cable loses and the soldering technique will make the measurement result was slightly change from the simulating result. However, the antenna design satisfied the proficiency necessity of the antenna which the frequency is drop at 2.5 GHz with the return loss is below than −10 dB.