Publication:
Nanoparticles in electrochemical bioanalytical analysis
Nanoparticles in electrochemical bioanalytical analysis
Date
2020-01-01
Authors
Rajapaksha R.D.A.A.
Uda Hashim
Subash Chandra Bose Gopinath
Nor Azizah Parmin
Fernando C.A.N.
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Research Projects
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Abstract
In the present biomedical field, most of the bioanalytical analyses depend on the electrochemical based systems. Nanomaterials are one of the key factors in enhancing the efficiency of analytical devices. Various nanomaterials such as metal NPs, metal oxide NPs, inorganic NPs, polymeric NPs, carbon-based, and polyoxometalates nanostructures can be seen in a variety of electrochemical analytical systems. Two-electrode, three-electrode, and multi-electrode-based miniaturized electrochemical analytical systems are popular in both research and commercially available systems. Properties of various nanostructures, and their involvement as surface functionalization material for label-free, and label-based ways in different biosensor applications have been discussed. Usage of various analytical methods such as potentiometry, voltammetry, amperometry, conductometry, coulometry, and impedimetric for detection, characterization, and quantification of nanostructure-based sensor systems, have been discussed. Further advantages of nanomaterials in biosensors and other electrodes in electrochemical analytical systems are also discussed. Compared to overall detection methods nanoparticle-based electrochemical analytical systems offer an approach to single molecular detection. By presenting theory to implementation, we hope this chapter provides a broad overview of usage and behavior of nanoparticles in electrochemical analytical systems, which may help readers understand and apply this phenomenon for future electrochemical-based biomedical analytical applications.
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Keywords
Biomaterial | Conductometry | DNA | Impedimetric | Nanostructures | Potentiometry | Protein | Self-assembly | Voltammetry