Nur Syakimah Ismail
Thumbnail Image
Preferred name
Nur Syakimah Ismail
Official Name
Nur Syakimah, Ismail
Alternative Name
Nur, Syakimah Ismail
Ismail, N. Syakimah
Ismail, Nur Syakimah Binti
Ismail, N. S.
Main Affiliation
Scopus Author ID
56402634600
Researcher ID
HKN-0608-2023

Research Output

Filters

1
4
Reset filters

Settings
Now showing 1 - 4 of 4
  • Publication
    Fabrication of Graphene Electrode via Graphene Transfer Method for Bisphenol A (BPA) Detection
    ( 2021-01-01)
    Shukri N.I.B.A.
    ;
    Norhayati Sabani
    ;
    Ruslinda A. Rahim
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Syarifah Norfaezah Sabki
    ;
    Nur Hamidah Abdul Halim
    ;
    Nur Syakimah Ismail
    Exposure of BPA is a concern as BPA can seep into food or beverages from containers and can possibly effects on human health especially endocrine systems. An electrochemical-based aptasensor utilizing graphene was developed in detecting endocrine disrupting compound Bisphenol A (BPA, 4,4'-(propane-2,2-diyl) diphenol). The graphene modified electrode was developed via graphene transfer. Fabrication and characterization of graphene transfer was studied in this paper using Scanning Electron Microscopy (SEM) and High-Power Microscope (HPM). In this research, the investigation of interfacial characteristic modified graphene with aptasensor and recognition of BPA with aptasensor had been done using electrochemical impedance spectroscopy (EIS). The increment of charge transfer resistance (Rct) before and after recognition of BPA denoting the accumulation of charge at the electrode surface in this research.
  • Publication
    Nanocrystalline diamond electrolyte-gates in field effect transistor for a prolific aptasensing HIV-1 tat on hydrogen-terminated surface
    (Universiti Malaysia Perlis (UniMAP), 2020-04)
    Nurul Atiqah Ahmad
    ;
    Ruslinda A. Rahim
    ;
    Bohuslav Rezek
    ;
    Alexander Kromka
    ;
    Nur Syakimah Ismail
    ;
    Subash Chandra Bose Gopinath
    ;
    Tibor Izak
    ;
    Vaclav Prochazka
    ;
    Fatin Nabilah Mohd Faudzi
    ;
    Azrul Syafiq Zainol Abidin
    ;
    Nur Nasyifa Mohd Maidizn
    Nanocrystalline diamonds have recently gained great attention to circumvent the current hurdles, with their appealing properties such as high-surface-area to volume ratio, low-background current, wide potential window, biocompatibility, and chemical stability. The nanocrystalline diamonds electrolyte-gated field-effect transistor (NCD-EGFET) can operate directly in solution without involving gate oxides in bringing the hydrogen-tethered moieties and facilitates the p-type surface conductivity. This research investigated on Trans-activator of transcription (Tat) protein; a powerful viral gene activator that plays a pivotal role in the primary stage of the human immunodeficiency virus type 1 (HIV-1) replication. Dose-dependent interactions of HIV-1 Tat on NCD-EGFET-based RNA aptamer sensing surface were monitored and attained the detection down to 10 fM. The linear regression curve with 3σ estimation professed the sensitivity range to be 31.213 mV/log10 [Tat Concentration]M and the limit of detection of 6.18 fM. The selectivity analysis of NCD-EGFET was conducted with different proteins from HIV (Nef and p24) and Bovine Serum Albumin. Furthermore, to practice in the clinical application, HIV-1 Tat was spiked into the human blood serum and it displayed the genuine non-fouling interaction with the aptamer. The attained high-performance signal enhancement with nanocrystalline diamond-biosensing aids to circumvent the issues in the current diagnosis.
  • Publication
    Fabrication of electrolyte-gate nanocrystalline diamond-based field effect transistor (NCD-EGFET) for HIV-1 Tat protein detection
    ( 2020-03-18)
    Ahmad, Nurul Atiqah
    ;
    Ruslinda A. Rahim
    ;
    Nur Syakimah Ismail
    ;
    Rezek B.
    In this paper, we reported on the fabrication process of electrolyte-gate field effect transistor using nanocrystalline diamond as a sensing transducer. The fabrication procedure was begin with the growth of nanocrystalline diamond thin film on silicon/silicon dioxide (Si/SiO2) substrate using microwave plasma-enhanced chemical vapour deposition (CVD). Then the photolithography process was performed in order to design and pattern the field effect transistor device with the active gate channel of 60 m length and 20 m width. Each device consists of three active gate channel which connecting to three different pairs of source and drain contact. The surface morphology of fabricated NCD-EGFET was characterized using Scanning Electron Microscope to clarify the active gate channel of the device and the grain size of nanocrystaline diamond. The current-voltage (I-V) measurement of the device were carried out to study the electrical behaviour for HIV-1 Tat protein detection via RNA aptamer as sensing probe.
      1  31
  • Publication
    Electrochemical study of TiO2 thin film on aluminium electrode for glucose detection
    ( 2020-01-08)
    Yen F.S.
    ;
    Halim N.H.A.
    ;
    Norhayati Sabani
    ;
    Ruslinda A. Rahim
    ;
    Nur Syakimah Ismail
    This paper presents the fabrication of Interdigitated Electrodes (IDEs) towards the detection of glucose. The transducer is constructed based on IDE because of its single layer electrode structure. Majority of IDE used metal such as gold and nickel as the electrodes because of their excellent electrical performances. However, in this paper, aluminium is applied as metal of electrodes not only because of its stable material but also trying to investigate the interaction between aluminium metal and Titanium dioxide, TiO2 with glucose detection. Titanium dioxide has been utilized as thin film on the deposited aluminium electrodes to increase the interaction between aluminium electrodes with different concentration of glucose solution. The designs of IDEs interdigitated array (IDBA) and interdigitated ring array (IDRA) are performed by using AUTOCAD and it is printed on a transparency paper as a mask. Customary photolithography methods with positive resist are applied to transfer the pattern on a silicon wafer in this fabrication process. Then, the fabricated IDEs are viewed and examined under Scanning Electron Microscope (SEM) and Atomic Force Microscope (AFM) to verify the surface morphology and topology. The electrochemical performance of IDEs is observed through cyclic voltammogram characteristics performed using potentiostat. In the nut shell, both IDBA and IDRA are tested within 0 to 100 mM range of glucose concentration.
      1  25