Khairul Farihan Kasim
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Preferred name
Khairul Farihan Kasim
Official Name
Kasim, Khairul Farihan
Alternative Name
Khairul, F. K.
Kasim, K. F.
Khairul Farihan, K.
Farihan Kasim, Khairul
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Scopus Author ID
57195982318
Researcher ID
AAK-3088-2021

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  • Publication
    Kinetic Extraction of Antioxidant and Total Phenoloc Content of Clinachantus nutans
    ( 2020-07-09)
    Aqilah Abd Rahim, Syafiqah
    ;
    Nuradibah Mohd Amer
    ;
    Khairul Farihan Kasim
    Clinacanthus nutans or Belalai Gajah is one of the herbs that contain natural antioxidant. This natural antioxidant can be used commercially in food as well as pharmaceutical industries. This research explored antioxidant of C. nutans and it was extracted by using solid-liquid extraction. Antioxidant of C. nutans extract was determined by using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and Total Phenolic Content (TPC) were determined using Folic-Ciocalteau reagent. Screening of the suitable particle size to be used in the extraction of C. nutans shows that mixture and leaves of C. nutans with particle size <63 μm was the best to obtain the highest DPPH scavenging activity. However, only mixture of C. nutans sample was used for the thermal extraction kinetic due to the availability of the samples. Thermal extraction kinetic of DPPH was fitted to the exponential growth model and show a good fit with R^2 = 0.9921. When transformed, the data gave a linear Arrhenius plot, R^2=0.717 with an activation energy of 17.35 x 0.108 kJ/mol. Thermal extraction kinetic of TPC was fitted to the exponential growth model and show a good fit with R^2 = 0.9892. When transformed, the data gave a linear Arrhenius plot, R^2=0.897 with an activation energy of 5.3832 x 0.451 kJ/mol. The model is adequate to predict DPPH scavenging activity and TPC of the C. nutans extracts with no significant different of the prediction and validation conducted at temperature of 70 °C for 30 min.
  • Publication
    Effects of steam pretreated rice biomass condensate containing soluble solid inhibitors on disruption of Pomacea Canaliculata egg
    ( 2023-07)
    Nor Azahanim Khamis
    ;
    Saleha Shamsudin
    ;
    Muhammad Hafiz Zabidi
    ;
    Khairul Farihan Kasim
    ;
    Ezyana Kamal Bahrin
    Pomacea canaliculata is an invasive freshwater snail species that has become a serious pest of rice in irrigation and paddy fields and is popularly known as the golden apple snail. They are species that are capable of surviving and spreading rapidly, causing significant changes in the ecosystem. The application of natural by-products of a physicochemical method of biomass steam pre-treated condensate is one option for disrupting Pomacea Canaliculata egg. This experiment was conducted to investigate the feasibility of steam pre-treated rice biomass condensate which contained soluble solid inhibitors as a biopesticide to eradicate Pomacea canaliculata. Rice straw, rice husk, and a combination of rice straw and rice husk (1:1) were pre-treated by the saturated steam pre-treatment in a batch reactor at high temperatures (190°C and 210°C) for 10 min. The steam condensate produced from this system was analysed for major degraded products or inhibitors such as furfural, hydroxymethylfurfural (HMF), and phenol. The steam condensate which contained soluble solid inhibitors was then analysed for solubility test on P. canaliculata eggs. The effect of soluble solid inhibitors on the eggs was structurally examined by using a scanning electron microscope (SEM). The results revealed that rice husk which was pre-treated at 210°C reflected the highest contents of furfural (0.300 g/L), HMF (1.670 g/L), and phenol (0.087 g/L). However, the combination of rice biomass sample (1:1) condensate at 210°C demonstrated the greatest solubility percentage (11.51%) when treated to the eggs P. canaliculata eggs. The image of the egg structure examined by SEM clearly displayed the fractures forming on the cuticle layer of the eggs. SEM results demonstrated that the condensate from saturated steam pre-treated rice biomass has the possibility to be used as a biopesticide to disrupt the eggs and eventually could prevent the snails’ invasion.
  • Publication
    Optimization of natural dye extraction from coconut husk
    ( 2023-07)
    Nur Ain Abdul Ghafar
    ;
    Khairul Farihan Kasim
    ;
    Nawwal Abdul Kadir
    This work aims to optimize the extraction of natural dye from coconut husks for use in the textile industry. The optimization process was carried out using the One-Factor-at-a-Time (OFAT) approach. Before optimization, different parts of the coconut husk i.e., endocarp, exocarp, mesocarp, and a mixture of mesocarp and exocarp were screened for their potential to be used as dye. It was found that the combination of mesocarp and exocarp has the highest potential in terms of physicochemical and phytochemical properties as it resulted in the best yield of extract, pH and colour intensity, and the highest Total Flavonoid Content, Total Phenolic Content, and Total Tannin Content. The optimal parameters to extract dye from coconut husk (combination of mesocarp and exocarps) are particle size of 2 mm, sample to solvent ratio of 1:100, extraction time of 60 min, and a temperature of 100 °C. The dye extract was tested for use on cotton fabric. It was found that regardless of the mordanting method, acetic acid is the best mordant to use. It resulted in a brighter and more intense colour than alum. The usage of acetic acid as the mordant combined with the pre-mordant method was found to be the best for colour fixation of the natural dye from coconut husk on cotton fabric.
  • Publication
    Encapsulation of Dicranopteris linearis extract using cellulose microparticles for antiulcer medication
    ( 2023-12-31)
    Ahmad A.A.
    ;
    Khairul Farihan Kasim
    ;
    Subash Chandra Bose Gopinath
    ;
    Anbu P.
    ;
    Sofian-Seng N.S.
    Dicranopteris linearis (DL) is a fern in the Gleicheniaceae family, locally known as resam by the Malay community. It has numerous pharmacological benefits, with antiulcer and gastroprotective properties. Peptic ulcer is a chronic and recurring disease that significantly impacts morbidity and mortality, affecting nearly 20 % of the world's population. Despite the effectiveness of peptic ulcer drugs, there is no perfect treatment for the ailment. Encapsulation is an advanced technique that can treat peptic ulcers by incorporating natural sources. This work aims to encapsulate DL extract using different types of cellulose particles by the solvent displacement technique for peptic ulcer medication. The extract was encapsulated using methyl cellulose (MC), ethyl cellulose (EC), and a blend of ethyl methyl cellulose through a dialysis cellulose membrane tube and freeze-dried to yield a suspension of the encapsulated DL extracts. The microencapsulated methyl cellulose chloroform extract (MCCH) has a considerably greater level of total phenolic (84.53 ± 6.44 mg GAE/g), total flavonoid (84.53 ± 0.54 mg GAE/g), and antioxidant activity (86.40 ± 0.63 %). MCCH has the highest percentage of antimicrobial activity against Escherichia coli (2.42 ± 107 × 0.70 CFU/mL), Bacillus subtilis (5.21 ± 107 × 0.90 CFU/mL), and Shigella flexneri (1.25 ± 107 × 0.66 CFU/mL), as well as the highest urease inhibitory activity (50.0 ± 0.21 %). The MCCH particle size was estimated to be 3.347 ± 0.078 μm in diameter. It has been proven that DL elements were successfully encapsulated in the methyl cellulose polymer in the presence of calcium (Ca). Fourier transform infrared (FTIR) analysis indicated significant results, where the peak belonging to the C[dbnd]O stretch of the carbonyl groups of methyl cellulose (MC) shifted from 1638.46 cm−1 in the spectrum of pure MC to 1639.10 cm−1 in the spectrum of the MCCH extract. The shift in the wavenumbers was due to the interactions between the phytochemicals in the chloroform extract and the MC matrix in the microcapsules. Dissolution studies in simulated gastric fluid (SGF) and model fitting of encapsulated chloroform extracts showed that MCCH has the highest EC50 of 6.73 ± 0.27 mg/mL with R2 = 0.971 fitted by the Korsmeyer-Peppas model, indicating diffusion as the mechanism of release.
      3
  • Publication
    A novel mosquitoes repellent soap based on Azadirachta indica and Eucalyptus citriodora oil
    ( 2005)
    Khairul Farihan Kasim
    ;
    Harbant, S.
    ;
    Hunter, M.
    ;
    Mohd Noor Ahmad
    The use of Azadirachta indica and Eucalyptus citriodora oil is a two stage repellent system for the soap, where E. citriodora offers short term repellency and the A. indica component offers longer term efficacy effects. Both materials (A. indica and E. citriodora) are from natural sources and locally available. This is the first time the two natural agents have been combined into a single product, thus providing synergy and longer term residual efficacy than present herbs and E. citriodora oil used in similar types of products in the market. This is cost effective product to combat mosquitoes as well as personal soap for everyday use.
      9  60
  • Publication
    Effects of steam pretreated rice biomass condensate containing soluble solid Inhibitors on disruption of Pomacea Canaliculata Egg
    ( 2023-07)
    Nor Azahanim Khamis
    ;
    Saleha Shamsudin
    ;
    Muhammad Hafiz Zabidi
    ;
    Khairul Farihan Kasim
    ;
    Ezyana Kamal Bahrin
    Pomacea canaliculatais an invasive freshwater snail species that has become a serious pest of rice in irrigation and paddy fields and is popularly known as the golden apple snail. They are species that arecapable of surviving and spreading rapidly, causing significant changes in the ecosystem. The application of natural by-products of a physicochemical method of biomass steam pre-treated condensate is one option for disrupting Pomacea Canaliculata egg. This experiment was conducted to investigate the feasibility of steam pre-treated rice biomass condensate which contained soluble solid inhibitors as a biopesticide to eradicate Pomacea canaliculata. Rice straw, rice husk, and a combination of rice straw and rice husk (1:1) were pre-treated by the saturated steam pre-treatment in a batch reactor at high temperatures (190°C and 210°C) for 10 min. The steam condensate produced from this system was analysed for major degraded products or inhibitors such as furfural, hydroxymethylfurfural (HMF), and phenol. The steam condensate which contained soluble solid inhibitors was then analysed for solubility test on P. canaliculata eggs. The effect of soluble solid inhibitors on the eggs was structurally examined by using a scanning electron microscope (SEM). The resultsrevealed that rice husk which was pre-treated at 210°C reflected the highest contents of furfural (0.300 g/L), HMF (1.670 g/L), and phenol (0.087 g/L). However, the combination of rice biomass sample (1:1) condensate at 210°C demonstrated the greatest solubility percentage (11.51%) when treated to the eggs P. canaliculata eggs. The image of the egg structure examined by SEM clearly displayed the fractures forming on the cuticle layer of the eggs. SEM results demonstrated that the condensate from saturated steam pre-treated rice biomass has the possibility to be used as a biopesticide to disrupt the eggs and eventually could prevent the snails’ invasion.
      7  33
  • Publication
    Optimization of natural dye extraction from coconut husk
    ( 2023-07)
    Nur Ain Abdul Ghafar
    ;
    Khairul Farihan Kasim
    ;
    Nawwal Abdul Kadir
    This work aims to optimize the extraction of natural dye from coconut husks for use in the textile industry. The optimization process was carried out using the One-Factor-at-a-Time (OFAT) approach. Before optimization, different parts of the coconut husk i.e., endocarp, exocarp, mesocarp, and a mixture of mesocarp and exocarp were screened for their potential to be used as dye. It was found that the combination of mesocarp and exocarp has the highest potential in terms of physicochemical and phytochemical properties as it resulted in the best yield of extract, pH and colour intensity, and the highest Total Flavonoid Content, Total Phenolic Content, and Total Tannin Content. The optimal parameters to extract dye from coconut husk (combination of mesocarp and exocarps) are particle size of 2 mm, sample to solvent ratio of 1:100, extraction time of 60 min, and a temperature of 100 °C. The dye extract was tested for use on cotton fabric. It was found that regardless of the mordanting method, acetic acid is the best mordant to use. It resulted in a brighter and more intense colour than alum. The usage of acetic acid as the mordant combined with the pre-mordant method was found to be the best for colour fixation of the natural dye from coconut husk on cotton fabric
      4  141
  • Publication
    Effect of extraction conditions on the phytochemical properties of Clinacanthus nutans using Pressurized Hot Water Extraction (PHWE) technique
    (IOP Publishing Ltd, 2020)
    M.K. Abduljabbar
    ;
    Khairul Farihan Kasim
    ;
    Akmal Hadi Ma’Radzi
    ;
    N.S. Sofian-Seng
    Clinacanthus nutan is an important herb species from the family Acanthaceae and is commonly found in Southeast Asia. It is also known as snake grass, or 'belalai gajah' in malay. The leaves of C. nutan can be used to make a refreshing juice or tea, or even consumed raw as 'ulam', a traditional malay salad. In this work, the leaves, stems, and a mixture of both leaves and stems of C. nutan are first dried in an oven at 50 C for 24 hours and then grounded into a powder. Then, pressurized hot water extraction (PHWE) is used to extract phytochemicals from the powdered samples at 120 C for 20 minutes. This work investigates the effects of three important parameters for extraction; the sample particle size (<63 to 500μm), solventto-sample ratio (10:2 to 50:2 v/w), and sample weight (0.5 to 3.0g) on the extracted phytochemicals' total phenolic compounds (TPC), total flavonoid compounds (TFC), and 2,2-dipheny1-1picrylhydrazyl (DPPH) scavenging activity. The experiments are carried out in triplicate and the results are analyzed using Minitab. Phytochemicals extracted from 2g leaf powder samples of particle size <63μm using a solvent-tosample ratio of 50:2 (v/w) resulted in the most favorable results for TPC, TFC, and DPPH scavenging activity.