The construction industry is growing extraordinarily, progressive and profitable. It is one of the topmost sectors that contribute to the economy of a country. Even so, it is the riskiest industry as construction workplace has the highest number of fatality and injuries. Safety and health issues remain critical to the construction industry due to its working environment and the complexity of working practices. When related to health, hygiene is one factor to be observed, in which safety is a primary concern in the construction sector. Hygiene, being part of safety and health management in site plays a significant role in the performance of an organization. At some extent, ignorance of hygiene resulted catastrophically. The present study found the influence of industry hygiene towards innovation performance in the construction industry. The industrial hygiene which measured through few dimensions, i.e. hygiene knowledge, personal hygiene behaviour and hygiene personnel protection equipment are tested against innovation performance as the dependent variable. Following the comprehensive reviews, it is pertinent for the research to choose a quantitative undertaking, where questionnaires survey is the primary tool to collect the data among the construction companies, i.e., developers and contractors that registered with CIDB. The instrument will be developed to investigate the influence of industrial hygiene practices toward innovation performance. The research objectives will be achieved by statistically analyzing the collected data with Structural Equation Modeling (SEM) to verify the relationship between the variables.