Publication:
Gold-nanoparticle associated deep eutectic solution mediates early bio detection of ovarian cancer

Simple item page
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtualsource.department 9fb002ae-804a-408b-a407-12683fa3a7bd
cris.virtualsource.department cbc99d4d-6211-466b-bb62-06960f8c24ca
cris.virtualsource.department 3f983c2e-28f9-4f7e-9c19-b081a6c20fd8
cris.virtualsource.department 8e981558-c63e-4656-a506-43e62c5327b0
cris.virtualsource.department f61ba939-dfbd-4d1f-9275-752ad9b8e59d
cris.virtualsource.department 68ee25e1-5fda-40a0-a39c-ded2003ba743
cris.virtualsource.department 1d59afd7-bda9-4ad0-9cb9-5ab04df0eaf6
cris.virtualsource.department aa6453eb-4e26-4a2c-9d9c-d81f720d4cc6
cris.virtualsource.department 7cf8efac-b639-4e2d-b7ff-5806a100f120
dc.contributor.author S. Uvambighai Devi
dc.contributor.author Nor Azizah Parmin
dc.contributor.author N. Fareezah Jaapar
dc.contributor.author F. Syakirah Halim
dc.contributor.author Uda Hashim
dc.contributor.author Subash Chandra Bose Gopinath
dc.contributor.author Muhammad Nur Aiman Uda
dc.contributor.author Voon Chun Hong
dc.contributor.author Mohammad Nuzaihan Md Nor
dc.contributor.author Adilah Ayoib
dc.contributor.author Shahidah Arina Shamsuddin
dc.contributor.author Norizah Abd Karim
dc.date.accessioned 2025-02-28T07:52:30Z
dc.date.available 2025-02-28T07:52:30Z
dc.date.issued 2025-01
dc.description.abstract Gold nanoparticles (AuNPs) have indeed been extensively researched in biological and photothermal therapy applications in recent years. This study aims to enhance the sensitivity of biosensors for early detection of ovarian cancer biomarkers by investigating the efficacy of DES-mediated surface functionalization of AuNPs. Additionally, the impact of DES on the stability and dispersion of AuNPs on SiO2 support is assessed to optimize sensor performance. A simple DES-mediated synthesis method for efficient amine surface functionalization of silicon dioxide (SiO2) to incorporate tiny AuNPs for antibody biosensors. Physical characterization [Scanning Electron Microscope (SEM), Ultraviolet-Visible Spectrophotometer (UV-Vis), Fourier Transform Infrared Spectroscopy (FTIR), and 3D Profiler] and electrical characterization (Keithley) have been done to determine the functionalization of the modified IDE surface. SEM analysis indicated the resultant nanoparticles have truncated spherical shapes. There is just a peak recorded by UV-Vis at 504-540 nm with AuNPs due to the formation of monodispersed AuNPs. When the conjugation of DES with samples is measured, the curves are identical in form, and the highest peak after conjugation has remained at 230 nm but the SPR absorption peak becomes narrower and moves toward greater wavelengths, indicating the conjugation between the molecules. Furthermore, when the DES is conjugated with AuNPs, 3-Aminopropyltriethoxysilane (APTES), antibody, and protein, the peaks gradually increased and became narrower, where O-H at 3280 cm-1, C-H at 2809 cm-1 and 2933 cm-1, CH2 at 1448 cm-1, CH3 at 1268 cm-1, C-OH at 1048 cm-1 and 1110 cm-1 and C-N+ at 844 cm-1 as analyzed by FTIR. Moreover, it can be observed that the 3D profilometer revealed a few red-colored areas, which are the portion that protrudes from the IDE surface. Based on the findings, it is possible to infer that this immunosensor does have the prospective to be used in clinical investigations for the precise detection of ovarian cancer or other biomarkers. The capacitance, transmittance, and resistivity profiles of the biosensor clearly distinguished between the antibody immobilization and the affinity binding. The presence of a DES-mediated synthetic approach increased the possibility of supporting different metal nanoparticles on SiO2 as the potential platform for biosensor applications.
dc.identifier.doi 10.58915/ijneam.v18i1.1685
dc.identifier.uri https://ejournal.unimap.edu.my/index.php/ijneam/article/view/1685/1049
dc.identifier.uri https://hdl.handle.net/20.500.14170/13717
dc.language.iso en
dc.relation.ispartof International Journal of Nanoelectronics and Materials (IJNeaM)
dc.relation.issn 1985-5761
dc.subject Biomarker
dc.subject Biosensor
dc.subject Nanomaterial
dc.subject Probe
dc.subject Surface chemistry
dc.title Gold-nanoparticle associated deep eutectic solution mediates early bio detection of ovarian cancer
dc.type Resource Types::text::journal::journal article
dspace.entity.type Publication
oaire.citation.endPage 46
oaire.citation.issue 1
oaire.citation.startPage 6
oaire.citation.volume 18
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Gold-nanoparticle associated Deep Eutectic Solution mediates early bio detection of Ovarian Cancer.pdf
Size:
813.17 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
International Journal of Nanoelectronics and Materials (IJNeaM)