Publication:
Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson's disease

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cris.author.scopus-author-id 57221190620
cris.author.scopus-author-id 57211581494
cris.author.scopus-author-id 58604039100
cris.author.scopus-author-id 57193702951
cris.author.scopus-author-id 46062073000
cris.author.scopus-author-id 58597614000
cris.author.scopus-author-id 57206966066
cris.author.scopus-author-id 57208665425
cris.author.scopus-author-id 57210595420
cris.author.scopus-author-id 6506246044
cris.author.scopus-author-id 7006558013
cris.author.scopus-author-id 36515899600
cris.virtual.department Universiti Malaysia Perlis
cris.virtualsource.department 3f983c2e-28f9-4f7e-9c19-b081a6c20fd8
dc.contributor.author Zhang R.
dc.contributor.author Wang S.
dc.contributor.author Huang X.
dc.contributor.author Yang Y.
dc.contributor.author Fan H.
dc.contributor.author Yang F.
dc.contributor.author Li J.
dc.contributor.author Dong X.
dc.contributor.author Feng S.
dc.contributor.author Anbu P.
dc.contributor.author Subash Chandra Bose Gopinath
dc.contributor.author Xin T.
dc.date.accessioned 2024-10-03T23:39:59Z
dc.date.available 2024-10-03T23:39:59Z
dc.date.issued 2020-01-15
dc.description.abstract α-synuclein is a predominantly expressing neuronal protein for understanding the neurodegenerative disorders. A diagnosing system with aggregated α-synuclein encoded by SNCA gene is necessary to make the precautionary treatment against Parkinson's disease (PD). Herein, gold-nanourchin conjugated anti-α-synuclein antibody was desired as the probe and seeded on single-walled carbon nanotube (SWCN) integrated interdigitated electrode (IDE). The surface morphology of SWCN-modified IDE and gold urchin-antibody conjugates were observed under FESEM, FETEM and AFM, the existing elements were confirmed. Voltammetry analysis revealed that the limit of fibril-formed α-synuclein detection was improved by 1000 folds (1 fM) with gold-nanourchin-antibody modified surface, compared to the surface with only antibody (1 pM). Validating the interaction of α-synuclein by Enzyme-linked Immunosorbent Assay was displayed the detection limit as 10 pM. IDE has a good reproducibility and a higher selectivity on α-synuclein as evidenced by the interactive analysis with the control proteins, PARK1 and DJ-1.
dc.identifier.doi 10.1016/j.aca.2019.10.012
dc.identifier.pmid 31761041
dc.identifier.scopus 2-s2.0-85074493960
dc.identifier.uri https://hdl.handle.net/20.500.14170/9082
dc.language.iso en
dc.relation.funding China National Funds for Distinguished Young Scientists
dc.relation.grantno 81100836
dc.relation.ispartof Analytica Chimica Acta
dc.relation.ispartofseries Analytica Chimica Acta
dc.relation.issn 00032670
dc.subject Fibril-formed α-synuclein
dc.subject Gold-nanocomposite
dc.subject Interdigitated electrode
dc.subject Prodromal parkinsonism
dc.subject Single-walled carbon nanotube
dc.title Gold-nanourchin seeded single-walled carbon nanotube on voltammetry sensor for diagnosing neurogenerative Parkinson's disease
dc.type Resource Types::text::journal::journal article
dspace.entity.type Publication
oaire.citation.endPage 150
oaire.citation.startPage 142
oaire.citation.volume 1094
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Shandong Provincial Hospital
oairecerif.affiliation.orgunit Inha University
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Shandong Provincial Qianfoshan Hospital
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Shandong University, China
oairecerif.author.affiliation Inha University, South Korea
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Shandong University, China
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person.identifier.scopus-author-id 57211581494
person.identifier.scopus-author-id 58604039100
person.identifier.scopus-author-id 57193702951
person.identifier.scopus-author-id 46062073000
person.identifier.scopus-author-id 58597614000
person.identifier.scopus-author-id 57206966066
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