Synthetic data by various algorithms that resemble actual data in terms of statistical features. Computer-aided medical applications have been extensively applied to model specific scenarios, such as medical imaging of retinal images for diabetic retinopathy (DR) detection. The available data and annotated medical data are typically rare and costly due to the difficulties of conducting medical screening and rely on highly trained doctors to review and diagnose. The modelling of retinal images for DR analysis is essential since it will provide a model to guide and test DR detection algorithms. This paper aims to model normal retina and non-proliferative diabetic retinopathy (NPDR) stages (mild, moderate, and severe) data models with the variation of dynamic models. The Digital Retinal Images for Vessel Extraction (DRIVE), The Standard Diabetic Retinopathy Database, Calibration Level 1 (DIARETDB1), and E-OPHTHA datasets are analyzed to obtain the specification of the human retina and DR lesions. In the data modelling phases, the model includes the bright and dark retinal lesions with the variation of dynamic parameters. 4100 synthetic images are used where 200 normal images and 3900 NPDR images to test the performance of DR detection algorithms over the full range of parameters.
