The purpose of conducting this study to explore the significant influence of Human Resources Management Practices (HRMP) on Innovation Work Behaviour (IWB). In this research there are four HRMP functions such compensation system, training and development (T&D), information sharing and supervisory support. This research is carried out by using a quantitative method through the distribution of questionnaires. Convenience sampling has been utilised in this research. The population of this study are employees of a manufacturing company located in the Northern Region of Malaysia, and the number of respondents who answered the questionnaire are 310. Data collected were classified, coded and then presented using SPSS. Based on the descriptive analyses, it is confirmed that the employees in this manufacturing company have high mean of rate for all variables: supervisory support (μ=4.80), information sharing (μ=4.79), compensation system (μ=4.76), Training and Development (μ=4.72) and IWB (μ=4.70). The result for correlation analyses presented that there is a strong influence of Training and Development (r=0.851); compensation system (r=0.621); information sharing (r=0.558); and supervisory support (r=0.532) towards employee’ IWB. Next, the accepted hypotheses are related to the influence of compensation system (β=0.147, p=0.003) and T&D (β=0.750, p=0.000) towards employees’ IWB. The implication presented that by providing a fair compensation system and introducing an appropriate T&D program, the company can increase the level of employees’ IWB. Given that, this study delivers an extensive knowledge on the influences of compensation system, T&D, information sharing and supervisory support on employees’ IWB.