Home
  • English
  • ÄŒeÅ¡tina
  • Deutsch
  • Español
  • Français
  • Gàidhlig
  • LatvieÅ¡u
  • Magyar
  • Nederlands
  • Português
  • Português do Brasil
  • Suomi
  • Log In
    New user? Click here to register. Have you forgotten your password?
Home
  • Browse Our Collections
  • Publications
  • Researchers
  • Research Data
  • Institutions
  • Statistics
    • English
    • ÄŒeÅ¡tina
    • Deutsch
    • Español
    • Français
    • Gàidhlig
    • LatvieÅ¡u
    • Magyar
    • Nederlands
    • Português
    • Português do Brasil
    • Suomi
    • Log In
      New user? Click here to register. Have you forgotten your password?
  1. Home
  2. Resources
  3. UniMAP Index Publications
  4. Publications 2021
  5. Single-walled carbon nanotube-gold urchin nanohybrid for identifying gastric cancer on dimicroelectrodes junction
 
Options

Single-walled carbon nanotube-gold urchin nanohybrid for identifying gastric cancer on dimicroelectrodes junction

Journal
Journal of the Taiwan Institute of Chemical Engineers
ISSN
18761070
Date Issued
2021-04-01
Author(s)
Yu Z.
Subash Chandra Bose Gopinath
Universiti Malaysia Perlis
Lakshmipriya T.
Anbu P.
DOI
10.1016/j.jtice.2021.04.016
Abstract
Diagnosing gastric cancer with a high accuracy helps in identifying at early stage and for a better treatment. A transcription factor, SRY-box containing gene-17 (SOX-17) shows a crucial role in the gastric cancer progression is desired as biomarker on a high-performance sensing platform, dimicroelectrodes Junction (DMEJ), constructed by the hybrid of single-walled carbon nanotube (SWCN) and gold urchin (GU) surface to detect the specific SOX-17 target oligonucleotide. SWCN was modified on DMEJ and GU conjugated capture DNA was immobilized on SWCN through the electrostatic interaction of GU by (3-Aminopropyl)triethoxysilane. Morphological analyses by FESEM and FETEM revealed the attachment of GU on SWCN with a uniform fashion. SWCN-GU modified DMEJ has enhanced an ideal electric flow and reflecting the capture DNA attachment. Reached the limit of detection at 1 aM, calculated on a linear curve (atto- to femto-molar) with the regression coefficient of R2 = 0.9909[y = 1.1226x + 1.3727]. Further, specificity of SOX-17 was confirmed by interacting complementary, single- and five-mismatched sequences of the target. In addition, the target DNA solution mixed human serum and control sequences did not interfere with the specific duplex formation, indicating the non-biofouling on DMEJ surface. This SWCN-GU constructed DMEJ surface helps to identify lower expression of SOX-17 and diagnosing gastric cancer progression.
Funding(s)
Universiti Malaysia Perlis
Subjects
  • Carbon material | Die...

File(s)
Research repository notification.pdf (4.4 MB)
Views
2
Acquisition Date
Nov 19, 2024
View Details
google-scholar
Downloads
  • About Us
  • Contact Us
  • Policies