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  1. Home
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  4. Publications 2020
  5. MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer
 
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MicroRNA-155 complementation on a chemically functionalized dual electrode surface for determining breast cancer

Journal
3 Biotech
ISSN
2190572X
Date Issued
2020-06-01
Author(s)
Subash Chandra Bose Gopinath
Universiti Malaysia Perlis
Perumal V.
Xuan S.
DOI
10.1007/s13205-020-02261-x
Handle (URI)
https://hdl.handle.net/20.500.14170/9289
Abstract
This study correlated and quantified the expression of microRNA-155 with breast cancer to determine breast cancer progression. The target microRNA-155 sequence was identified by complementation on a capture-probe sequence-immobilized interdigitated dual electrode surface. The sensitivity was found to be 1 fM, and the limit of detection fell between 1 and 10 fM. The specific sequence selectivity with single mismatches, triple mismatches, and noncomplementary bases failed to complement the capture-probe sequence. The obtained results demonstrate the selective determination of the microRNA-155 sequence and can help to diagnose breast cancer.
Subjects
  • Biosensor | Breast ca...

File(s)
Research repository notification.pdf (4.4 MB)
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