Ramzan Mat Ayub
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Preferred name
Ramzan Mat Ayub
Official Name
Ramzan, Mat Ayub
Alternative Name
Mat Ayub, R.
Ayub, R. Mat
Ayub, R. M.
Ayub, Rm
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Scopus Author ID
21741780500

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  • Publication
    Lectin bioreceptor approach in capacitive biosensor for prostate-specific membrane antigen detection in diagnosing prostate cancer
    ( 2021-03-01)
    Subramani I.G.
    ;
    Ramzan Mat Ayub
    ;
    Subash Chandra Bose Gopinath
    ;
    Perumal V.
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Mohd Khairuddin Md Arshad
    This research reports a new approach with lectin-based capacitive non-faradaic biosensor for the detection of prostate-specific membrane antigen (PSMA) as a promising diagnostic marker for determining prostate cancer. PSMA expression is significantly higher in malign hyperplasia, thus can be effectively employed to discriminate other benign prostatic diseases. Herein, the aluminium interdigitated electrode was fabricated and modified by a linker, 2-mercaptoacetate to form the self-assembled monolayer. Gold nanoparticles were used as a signal amplifier and supported the conjugation of Concanavalin A, for efficient capacitive sensing of PSMA. Scanning electron microscope observation effectively captured the surface modification on the aluminium surface by revealing the specific adherence of gold nanoparticles with Concanavalin A. Moreover, the successful surface modification was further validated by atomic force microscopy, Fourier transforms infrared spectroscopy, and X-ray photoelectron spectroscopy. The interaction analysis of Concanavalin A with PSMA by capacitive non-faradaic measurement exhibited a linear detection range from 10 pM to 100 nM and attained the detection limit and sensitivity of 10 pM and 1.65 nF/pM respectively as the comparable performance to the current sensing strategies. Furthermore, the fabrication and quantification of PSMA as demonstrated here are relatively simple and can be employed for the straightforward detection of other biomarkers.
  • Publication
    Design and simulation of Cylindrical Stacked Silicon Nanowire (SiNW) field-effect transistors
    (IEEE, 2023-12)
    H’ng Chee Chang
    ;
    Mohd Khairuddin Md Arshad
    ;
    Mohamad Faris Mohamad Fathil
    ;
    Mohammad Nuzaihan Md Nor
    ;
    Subash Chandra Bose Gopinath
    ;
    Ramzan Mat Ayub
    In continuous effort to increase the current drive without sacrificing the off current and better off gate control on the channel, the MOSFET devices have advanced from classical, planar, single-gate and three-dimensional devices with multi-gate structures. Recently, multi-bridge-channel technology has become a feasible solution beyond FinFET multi-gate structure. In this work, we design Gate-All-Around (GAA) based on silicon nanowire. Numerical simulation based Silvaco Device tools has been used to design multiple number of cylindrical nanowires, then followed by different channel diameter, consisting of 20, 30 and 40 nm. The devices are the characterized on transconductance, threshold voltage, DIBL and subthreshold slope. The simulation results indicate that the device performance is best at a nanowire diameter of 20 nm due to improved gate control over charge distribution. Regarding the number of nanowires, the voltage performance is not significantly affected by Nnw =1 or higher. However, higher numbers of nanowires, such as Nnw = 3, demonstrate improved drain current and transconductance.