The Autodesk Moldflow Insight (AMI) software was used in this study to focuses on the analysis in plastic injection moulding process associate the input parameter and output parameter. The material used in this study is Acrylonitrile Butadiene Styrene (ABS) as the moulded material to produced the plastic part. The MATLAB sortware is a method was used to find the best setting parameter. The variables was selected in this study were melt temperature, packing pressure, coolant temperature and cooling time.