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Cost-effective fabrication of polydimethylsiloxane (PDMS) microfluidics for point-of-care application

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cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtualsource.department 1d59afd7-bda9-4ad0-9cb9-5ab04df0eaf6
cris.virtualsource.department cbc99d4d-6211-466b-bb62-06960f8c24ca
cris.virtualsource.department aa6453eb-4e26-4a2c-9d9c-d81f720d4cc6
cris.virtualsource.department b62964ae-c29c-4ae7-9b7e-ae1d7b2551eb
cris.virtualsource.department 9fb002ae-804a-408b-a407-12683fa3a7bd
dc.contributor.author Adilah Ayoib
dc.contributor.author Noor Amalina Aini Abdul Karim
dc.contributor.author Uda Hashim
dc.contributor.author Shahidah Arina Shamsuddin
dc.contributor.author Siti Fatimah Abd Rahman
dc.contributor.author Mohamad Faris Mohamad Fathil
dc.contributor.author Nor Azizah Parmin
dc.date.accessioned 2024-11-06T03:37:18Z
dc.date.available 2024-11-06T03:37:18Z
dc.date.issued 2024-06
dc.description.abstract Microfluidics fabrication pertains to the construction of small-scale devices and systems that manipulate and control small volumes of fluids. This process involves precise engineering and manufacturing procedures aimed at designing and producing these devices, which find applications in healthcare, environmental monitoring, and chemical analysis. The present study showcases an inexpensive approach to fabricate microfluidics channels using PDMS biopolymer and soft lithography technique to achieve laminar fluid flow. Initially, a robust and adhesive mold was created by fabricating a master template using several layers of SU-8 5 and SU-8 2015 negative photoresists. Subsequently, PDMS microfluidics channels were replicated and sealed onto a glass substrate through plasma bonding treatment. High-power microscopy images and profilometer analyses demonstrated successful fabrication with minimal deviation from the initial designs and the fabricated devices (less than 0.07 mm, less than 0.6°). Both the SU-8 master template and PDMS replicate displayed average microchannel height values and surface roughness of 100 μm and 0.26 μm or lower, respectively. Additionally, the fluid test confirmed laminar flow without any leakage post plasma oxidation, indicating the completion of an efficient and cost-effective fabrication process.
dc.identifier.uri https://ejournal.unimap.edu.my/index.php/ijneam/issue/view/66
dc.identifier.uri https://hdl.handle.net/20.500.14170/9678
dc.language.iso en
dc.relation.ispartof International Journal of Nanoelectronics and Materials (IJNeaM)
dc.relation.issn 1985-5761
dc.subject SU-8 photoresist
dc.subject Fabrication
dc.subject PDMS
dc.subject Microfluidics
dc.subject Soft Lithography
dc.subject Point-of-care analysis
dc.title Cost-effective fabrication of polydimethylsiloxane (PDMS) microfluidics for point-of-care application
dc.type Resource Types::text::journal::journal article
dspace.entity.type Publication
oaire.citation.endPage 151
oaire.citation.issue 6 (Special Issue IconMAR 2023)
oaire.citation.startPage 143
oaire.citation.volume 17
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Sains Malaysia
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
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