Business model innovation has provided a new space for the dynamic development of networks driven by the evolution of digital technology as a modern approach to the realisation of business sustainability (BS). Specifically, in modern business, technology supports the new digital economy, which places increasing demands on human intelligence. However, BS should be seen in the context of efforts to build competitive advantage by using an ethical approach to support innovative solutions that have a positive impact on society. The achievement is not only the result of careful analysis but also 'responsibility'. Consequently, in the digital era, professionalism is not only in terms of knowledge or skills related to technology adoption; professional ethical standards determine BS. Therefore, the purpose of this study is to explore the extent to which EO (EO), through its components, formulates BS in the digital era through the role of professionalism in human resource as a mediator. A literature review method was applied in this study to provide a new model for the issue discussed. This study implies that EO encourages businessmen to become successful entrepreneurs in establishing BS in the digital era, mediated by the professionalism of human resource. Finally, this study provides a new approach to business problems as a strategy for anticipating the current dynamic environment. Besides, this study presents literature on the concepts of EO and BS for preparing professional human resource in the business sector to face the high competition in the digital era.
