Publication:
Enhanced antibacterial effect by antibiotic loaded starch nanoparticle

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cris.author.scopus-author-id 57192702706
cris.author.scopus-author-id 7006558013
cris.virtual.department Universiti Malaysia Perlis
cris.virtualsource.department 3f983c2e-28f9-4f7e-9c19-b081a6c20fd8
dc.contributor.author Nor Syahida Ismail
dc.contributor.author Subash Chandra Bose Gopinath
dc.date.accessioned 2025-01-13T14:44:09Z
dc.date.available 2025-01-13T14:44:09Z
dc.date.issued 2017-10-01
dc.description.abstract The soluble form of starch nanoparticle (SNP) is used for its advantage to encapsulate the antibiotics. In this study, SNP encapsulated antibiotics were introduced to the bacterium, Streptococcus pyogenes and the inhibitory effect was studied. The preparation of SNP loaded antibiotics was carried out using microemulsion nanoprecipitation method which does not require sophisticated equipment, hazardous reagents and extreme conditions. The starch was dissolved in urea alkaline solution and precipitated in ethanolic emulsion system which yields smaller sized nanoparticles with larger surface area thus increasing the efficiency of low water soluble drug molecules loading. The SNP obtained are not vulnerable to clumping. The antimicrobial study was done using the disk diffusion test with different amounts of starch loaded with antibiotics. The encapsulation of single/multiple antibiotics and their inhibition is an indicator of the efficacy of SNPs. This study improved the effectiveness of drugs capability that are produced from a cheap source that brought about a large impact.
dc.identifier.doi 10.1016/j.jaubas.2016.10.005
dc.identifier.scopus 2-s2.0-85007479677
dc.identifier.uri https://hdl.handle.net/20.500.14170/13408
dc.language.iso en
dc.relation.grantno undefined
dc.relation.ispartof Journal of the Association of Arab Universities for Basic and Applied Sciences
dc.relation.ispartofseries Journal of the Association of Arab Universities for Basic and Applied Sciences
dc.relation.issn 18153852
dc.rights open access
dc.subject Encapsulation | Microemulsion | Starch nanoparticle | Streptococcus pyogenes
dc.subject Starch nanoparticle
dc.subject Encapsulation
dc.subject Microemulsion
dc.subject Streptococcus pyogenes
dc.title Enhanced antibacterial effect by antibiotic loaded starch nanoparticle
dc.type Journal
dspace.entity.type Publication
oaire.citation.endPage 140
oaire.citation.startPage 136
oaire.citation.volume 24
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
person.identifier.orcid #PLACEHOLDER_PARENT_METADATA_VALUE#
person.identifier.orcid #PLACEHOLDER_PARENT_METADATA_VALUE#
person.identifier.scopus-author-id 57192702706
person.identifier.scopus-author-id 7006558013
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