One of the most common diseases in women of reproductive age is Polycystic Ovary Syndrome (PCOS). PCOS diagnosis can be tricky, because not everyone with PCOS has polycystic ovaries (PCO), nor does everyone with ovarian cysts have PCOS, hence the pelvic ultrasound as a stand-alone diagnosis is not sufficient. The full diagnostic plan is mainly a combination of a pelvic ultrasound besides blood tests of specific parameters that indicate the presence of PCOS. Since PCOS is a hard-to-diagnose widespread hormonal disorder, blood tests, symptoms, and other parameters with the help of a computer can form a new and easy method to diagnose it. Therefore, we had successfully built a high performing diagnostic model using MATLAB. The data was obtained from the website Kaggle, and the dataset is called Polycystic Ovary Syndrome. In this paper various machine algorithms were employed by utilizing seven classifiers. Results demonstrated that Linear Discriminant classifier exhibits the best performance in terms of accuracy, while in terms of sensitivity, the KNN classifier had the best result. Also, a comparison with four other research papers that exploited the same PCOS dataset was done in terms of implementation platforms, evaluation methods, classifiers, classes, accuracy, and precision of each classifier. Our research excelled among all in terms of accuracy and varied in precedence with precision. MATLAB had shown substantial results and a great model fitting embedded approaches, scoring a high accuracy and precision outcome compared to other studies. Other improvements on the overall PCOS prediction can involve employing preprocessed ultrasound images with the features presented in the dataset.