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Micro-interdigitated electrodes genosensor based on Au-deposited nanoparticles for early detection of cervical cancer

cris.author.scopus-author-id 57292695500
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cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtual.department Universiti Malaysia Perlis
cris.virtualsource.department 9fb002ae-804a-408b-a407-12683fa3a7bd
cris.virtualsource.department 4adedcbf-ff45-4d20-b878-2dd9a512619b
cris.virtualsource.department cbc99d4d-6211-466b-bb62-06960f8c24ca
cris.virtualsource.department 3f983c2e-28f9-4f7e-9c19-b081a6c20fd8
cris.virtualsource.department 8e981558-c63e-4656-a506-43e62c5327b0
dc.contributor.author Jaapar F. Nadhirah
dc.contributor.author Nor Azizah Parmin
dc.contributor.author Nur Hamidah Abdul Halim
dc.contributor.author Uda Hashim
dc.contributor.author Subash Chandra Bose Gopinath
dc.contributor.author Fatin Syakirah Halim
dc.contributor.author Muhammad Nur Aiman Uda
dc.contributor.author Amilia Afzan
dc.contributor.author Noorhashimah Mohamad Nor
dc.contributor.author Khairunisak Abdul Razak
dc.date.accessioned 2024-10-04T15:19:24Z
dc.date.available 2024-10-04T15:19:24Z
dc.date.issued 2023
dc.description.abstract Genosensor-based electrodes mediated with nanoparticles (NPs) have tremendously developed in medical diagnosis. Herein, we report a facile, rapid, low cost and highly sensitive biosensing strategy for early detection of HPV 18 using gold-nanoparticles (AuNPs) deposited on micro-IDEs. This study represents surface charge transduction of micro-interdigitated electrodes (micro-IDE) alumina insulated with silica, independent and mini genosensor modified with colloidal gold NPs (AuNPs), and determination of gene hybridization for early detection of cervical cancer. The surface of AuNPs deposited micro-IDE functionalized with optimized 3-aminopropyl-triethoxysilane (APTES) followed by hybridization with deoxyribonucleic acid (DNA) virus to develop DNA genosensor. The results of ssDNA hybridization with the ssDNA target of human papillomavirus (HPV) 18 have affirmed that micro-IDE functionalized with colloidal AuNPs resulted in the lowest detection at 0.529 aM. Based on coefficient regression, micro-IDE functionalized with AuNPs produces better results in the sensitivity test (R2 = 0.99793) than unfunctionalized micro-IDE.
dc.identifier.doi 10.1016/j.ijbiomac.2023.126745
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S0141813023036425?pes=vor&utm_source=scopus&getft_integrator=scopus
dc.identifier.uri https://www.sciencedirect.com/
dc.language.iso en
dc.publisher Elsevier
dc.relation.funding Ministry of Higher Education, Malaysia
dc.relation.grantno RACER/1/2019/TK04/UNIMAP/2
dc.relation.ispartof International Journal of Biological Macromolecules
dc.relation.issn 01418130
dc.subject Cervical cancer
dc.subject Genosensor
dc.subject Gold nanoparticles (AuNPs)
dc.subject Human papillomavirus (HPV)
dc.subject Interdigitated electrodes (IDEs)
dc.title Micro-interdigitated electrodes genosensor based on Au-deposited nanoparticles for early detection of cervical cancer
dc.type Journal
dspace.entity.type Publication
oaire.citation.endPage 14
oaire.citation.startPage 1
oaire.citation.volume 253
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.affiliation.orgunit Faculty of Medicine and Health Sciences
oairecerif.affiliation.orgunit School of Materials and Mineral Resources Engineering
oairecerif.affiliation.orgunit School of Materials and Mineral Resources Engineering
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.author.affiliation Universiti Putra Malaysia
oairecerif.author.affiliation Universiti Sains Malaysia
oairecerif.author.affiliation Universiti Sains Malaysia
oairecerif.citation.number 126745
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person.identifier.scopus-author-id 57292695500
person.identifier.scopus-author-id 57195835481
person.identifier.scopus-author-id 55493444600
person.identifier.scopus-author-id 22633937800
person.identifier.scopus-author-id 7006558013
person.identifier.scopus-author-id 57226870631
person.identifier.scopus-author-id 58099479900
person.identifier.scopus-author-id 58313807500
person.identifier.scopus-author-id 57223824820
person.identifier.scopus-author-id 57574138800
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