Herpes simplex virus (HSV) is one of the infecting human viruses. To achieve the entry of virion into the host cells, HSV requires 5 types of the glycoprotein, which are glycoprotein C (gC), glycoprotein D (gD), Glycoprotein B (gB) and a complex of glycoprotein H and glycoprotein L (gH-gL). All five glycoproteins are mandatory for HSV-host interaction and infection. There will be no invasion to the cells without involvement of these glycoproteins; there will be no cellular invasion. In this paper, we aligned the nucleotide sequences of glycoprotein B and glycoprotein D from herpes simplex types l & 2 virus. By comparing these nucleotide sequences between herpes simplex type l and type 2 viruses, we able to find out the conserved and non-conserved regions, which indicate the similarities and differences between glycoprotein B and glycoprotein D of these two human herpes viruses.
