Publication:
Fabrication of quartz crystal microbalance with pegylated lipopolymer for detection of non-invasive lung cancer biomarker
Fabrication of quartz crystal microbalance with pegylated lipopolymer for detection of non-invasive lung cancer biomarker
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Date
2019-01-01
Authors
Rahman N.A.A.A.
Ma'Radzi A.H.
Zakaria A.
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Research Projects
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Abstract
This study presents a fabrication of quartz crystal microbalance (QCM) with pegylated lipopolymer for detection of non-invasive lung cancer biomarkers. The selected biomarkers for this study were propanol, ethyl benzene, hexanal and decane. QCM with fundamental frequency 30 MHz AT-cut gold electrodes were coated with lipid and pegylated lipopolymer with a terminated functional group of carboxyl and succinyl to increase sensor responsiveness towards detection purposes. The fabricated sensors could detect all biomarkers with various selectivity and sensitivity responses. Furthermore, the results from biomarker exposure indicated that the sensitivity of sensors coated with succinyl, and carboxyl lipopolymer film were better than in detection toward propanol and hexanal, while lipid was best in detection towards ethyl benzene and decane.
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Keywords
Biomarker | Lung cancer | Pegylated lipopolymer | Quartz crystal microbalance | Volatile organic compound