Oil palm empty fruit bunch (EFB) was chemically activated by phosphoric acid and heat treatment to produce porous activated carbon (AC) for adsorption of copper ions from synthetic wastewater using static batch test. Copper adsorption process was optimized using Response Surface Method (RSM) by varying four operating parameters i.e. pH (A), initial concentration (B), adsorbent dosage (C) and contact time (D) through a quadratic model developed based on Central Composite Design (CCD) approach. Within the tested parameter range, copper adsorption was found to be at optimum condition at pH 5, initial concentration of 200 mg/L, adsorbent dosage of 0.55 g per 200 mL copper solution and contact time of 2.5 hours, yielding 52.5% of copper removal. A good agreement was achieved by comparing the predicted model with experimental data (R2=0.9618). All four operating parameters tested are significant in affecting the adsorption process, with pH being the most significant with an F-value of 171.70. The interaction between pH and initial concentration (AB) has the most significant interacting effects (F-value of 18.30), while quadratic effects of pH (A2) and adsorbent dosage (C2) are most significant with F-values of 62.80 and 42.58 respectively.