In this study, an attempt to develop the mechanical properties of PMMA that are used in dentures material by using polymers blends of (PMMA: 2%NR) and (PMMA: 2%SR) as a matrix reinforced with natural nanoparticles of Clove Powder (CP) that were added with different weight fractions of (0.0, 0.1%, 0.3%, 0.5% and 0.7%). Two groups of composites samples were prepared according to the type of polymer blends matrix by using the hand lay-up method. The maximum values of tensile strength and modulus of elasticity were noted at 65 MPa and 1.033 GPa respectively for polymer blend nanocomposite [(PMMA: 2%NR): 0.5% CP], whereas, the Shore D hardness reaches to a maximum value of (89) for polymer blend nanocomposite (PMMA: 2%NR): 0.7% CP). On the basis of these results, it can be concluded that the addition of CP in a nanometer size to polymer blends materials (PMMA: 2% NR) is one of the hopeful materials that can be utilized to develop the mechanical properties for dentures base applications.