Since the initial presentation of cell contact response with native topographic structure in 1911, numerous studies have been published to investigate how cells respond when interacting with micro/nano structures.. Many of the founding has potential to become applications in bio-medical or in pharmaceutical industry. Regardless of the huge prospect, these applications are still bound to the manufacturability of the micro/nano topographic structures. The introduction of nanoimprint lithography in 1995 has demonstrated that it can replicating micro/nano structures with relatively simple and low-cost equipment but with high throughput and high reliability. This paper reviews the development in cell-micro/nanotopographic interactions, the development of high throughput nanofabrication method. The nanofabrication methods in focus is nanoimprint lithography and electrospinning. This review paper also discusses the potential applications from cell-nanotopographic for mass productions. Prospectus applications such as the development in development of antimicrobial surfaces interactions and biologically inspired nanoscaffold and nanopattern suitable for tissue repair and regeneration are also discussed.
