Publication:
Coordination of Nanoconjugation with an Antigen/Antibody for Efficient Detection of Gynecological Tumors
Coordination of Nanoconjugation with an Antigen/Antibody for Efficient Detection of Gynecological Tumors
| cris.author.scopus-author-id | 57216493129 | |
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| cris.author.scopus-author-id | 57216484070 | |
| cris.author.scopus-author-id | 57216486187 | |
| cris.author.scopus-author-id | 7006558013 | |
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| cris.author.scopus-author-id | 20735994400 | |
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| cris.virtual.department | Universiti Malaysia Perlis | |
| cris.virtualsource.department | 3f983c2e-28f9-4f7e-9c19-b081a6c20fd8 | |
| dc.contributor.author | Liu X. | |
| dc.contributor.author | Yang X. | |
| dc.contributor.author | Shao J. | |
| dc.contributor.author | Hong Y. | |
| dc.contributor.author | Subash Chandra Bose Gopinath | |
| dc.contributor.author | Chen Y. | |
| dc.contributor.author | Wey M.C. | |
| dc.contributor.author | Wang Y. | |
| dc.date.accessioned | 2024-10-03T23:39:03Z | |
| dc.date.available | 2024-10-03T23:39:03Z | |
| dc.date.issued | 2020-01-01 | |
| dc.description.abstract | Cervical, ovarian, and endometrial cancers are common in the female reproductive system. Cervical cancer starts from the cervix, while ovarian cancer develops when abnormal cells grow in the ovary. Endometrial or uterine cancer starts from the lining of the womb in the endometrium. Approximately 12,000 women are affected every year by cervical cancer in the United States. Squamous cell carcinoma antigen (SCC-Ag) is a well-established biomarker in serum for diagnosing gynecological cancers, and its levels were observed to be elevated in cervical, ovarian, and endometrial cancer patients. Moreover, SCC-Ag was used to identify the tumor size and progression stages. Various biosensing systems have been proposed to identify SCC-Ag; herein, enhanced interdigitated electrode sensing is presented with the use of gold nanoparticles (GNPs) to conjugate an antigen/antibody. It was proved that the limit of detection is 62.5 fM in the case of antibody-GNP, which is 2-fold higher than that by SCC-Ag-GNP. Furthermore, the antibody-GNP-modified surface displays greater current increases with concomitant dose-dependent SCC-Ag levels. High analytical performance was shown by the discrimination against -fetoprotein and CYFRA 21-1 at 1 pM. An enhanced sensing system is established for gynecological tumors, representing an advance from the earlier detection methods. | |
| dc.identifier.doi | 10.1155/2020/6528572 | |
| dc.identifier.scopus | 2-s2.0-85083636486 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14170/9076 | |
| dc.language.iso | en | |
| dc.relation.grantno | undefined | |
| dc.relation.ispartof | Journal of Analytical Methods in Chemistry | |
| dc.relation.ispartofseries | Journal of Analytical Methods in Chemistry | |
| dc.relation.issn | 20908865 | |
| dc.rights | open access | |
| dc.title | Coordination of Nanoconjugation with an Antigen/Antibody for Efficient Detection of Gynecological Tumors | |
| dc.type | Journal | |
| dspace.entity.type | Publication | |
| oaire.citation.volume | 2020 | |
| oairecerif.affiliation.orgunit | Fifth Hospital of Xi'an | |
| oairecerif.affiliation.orgunit | The First Hospital of Xian Jiaotong University | |
| oairecerif.affiliation.orgunit | Universiti Malaysia Perlis | |
| oairecerif.affiliation.orgunit | Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine | |
| oairecerif.affiliation.orgunit | Universiti Malaysia Perlis | |
| oairecerif.affiliation.orgunit | Universiti Malaya | |
| oairecerif.affiliation.orgunit | Universiti Malaya | |
| oairecerif.affiliation.orgunit | Xi'an Children's Hospital | |
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| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
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| oairecerif.author.affiliation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| oairecerif.author.affiliation | Universiti Malaysia Perlis | |
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| oairecerif.citation.number | 6528572 | |
| person.identifier.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| person.identifier.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| person.identifier.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| person.identifier.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| person.identifier.orcid | 0000-0002-8347-4687 | |
| person.identifier.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| person.identifier.orcid | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| person.identifier.orcid | 0000-0003-1734-8487 | |
| person.identifier.scopus-author-id | 57216493129 | |
| person.identifier.scopus-author-id | 17344732300 | |
| person.identifier.scopus-author-id | 57216484070 | |
| person.identifier.scopus-author-id | 57216486187 | |
| person.identifier.scopus-author-id | 7006558013 | |
| person.identifier.scopus-author-id | 36645529800 | |
| person.identifier.scopus-author-id | 20735994400 | |
| person.identifier.scopus-author-id | 57216494478 |
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