In this paper, several techniques of image enhancement spatial domain is elucidated and analyzed for the purpose of enhancing Acute Myeloid Leukemia (AML) subtype of M1, M4, M5 and M7. The techniques involved contrast stretching of greyscale images, image subtraction and image sharpening. The three methods compared with one another to achieve the highest PSNR value for the suitability technique of AML subtypes (M1, M4, M5 and M7). Firstly, subtypes images converted into grayscale. Then, each four images tested with contrast stretching techniques followed by image subtraction and image sharpening. The performances were evaluated based on Mean Square Error (MSE) and Peak Signal to Noise Ratio (PSNR). Due to its higher value obtained, image sharpening is a good enhancement techniques for Acute Myeloid Leukemia with 68.2083 dB and the lowest MSE achieved of 0.0103.
