Looking at the lack of the research that emphasize on both practical design and measurement of the IEEE 802.16e Mobile WiMAX Power Amplifier (Mobile W1MAX PA) at present time, this work initiative presented a theoretically backed up but practical and industrial-based design method as well as measurement procedure for Mobile WiMAX PA. In this work, 27dBm (112 Watt) of Mobile WiMAX PA with efficiency of35.4% was successfully built and demonstrated. The transistor selected due to its suitability towards Mobile WiMAX critical requirements which are linearity and efficiency. This work emphasizes on designing Mobile WiMAX PA at 2.5GHzfor proof-ofconcept design and was expanded to 2.3GHz to 2. 7GHz frequency band for practicality. This was due to the fact that designing PAfor a wider band will enable a common PA to be applied for both typical IEEE 802.16 Mobile WiMAX and WiBRO environment without any further tuning. All typical design aspects and Mobile WiMAX P A measurement were discussed in details such as transistor selection criteria, transistor stability issue, linearity effect towards Mobile WiMAX P A, layout design considerations up to the aspect of thermal design and the importance of heat dissipation in Mobile WiMAX PA. In this work, few design tools were used to aid the PA design and optimization process such Smith Chart Tool for impedance matching network design, SPICE-based microwave circuit simulator for linear and large signal simulation as well as for microstrip design. A highly accurate method in designing microwave amplifier has been addressed which knawn as EM/Circuit Co-Simulation method. This method integrates a numerical-based EM simulator with SPICED-based microwave circuit simulator was capable to yield highly precise small signal parameters as compared to the measured performance. Through this method, very accurate outcome is achievable without spending too much time for circuit setup and post-production tuning. A complied to IEEE 802.16e Mobile WiMAX standards, a comparable measured and simulaJed results together with the practical design steps as the ultimate goals for this work were achieved by the design of this 2.5GHz IEEE 802.16e Mobile WiMAXPA.