Ahmad Anas Nagoor Gunny
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Preferred name
Ahmad Anas Nagoor Gunny
Official Name
Ahmad Anas, Nagoor Gunny
Alternative Name
Nagoor Gunny, Ahmad Anas
Gunny, A. A.N.
Nagoor Gunny, A. A.
Ahmad Anas, N. G.
Gunny, Ahmad Anas Nagoor
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Scopus Author ID
55940833700
Researcher ID
AFF-6251-2022

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  • Publication
    Antioxidant and xanthine oxidase inhibitory activity of euphorbia hirta leaves crude extract
    ( 2020-01-01)
    Ahmad Anas Nagoor Gunny
    ;
    Carmen T.
    ;
    Mat M.H.C.
    ;
    Nordin A.A.
    ;
    Nasir A.M.
    Today, exposure to free radicals and gout cases have been a concern, showing several health effects from synthetic medications and clinical drugs for antioxidant effect and xanthine oxidase inhibition effect, respectively; all of which lead to the discovery of natural inhibitors from medicinal plants. In this study, a green solvent known as the deep eutectic solvent is synthesised to replace conventional solvents for the extraction of free radical inhibitors and xanthine oxidase inhibitors from a medicinal plant that has shown many health benefits and is widely used in traditional medicine, the Euphorbia hirta. The leaves extract from Euphorbia hirta showed the highest inhibition (87.95 ± 0.0061%) on free radical assays. The IC50 for free radical inhibition of the leaves extract is 10.56 ± 0.58 µg/mL. The IC50 value for xanthine oxidase inhibition of allopurinol was the lowest, which was at 6.94 ± 0.32 µg/mL; while the leaves extract of Euphorbia hirta exhibited value at 9.40 ± 0.13 µg/mL. The correlation value between the antioxidant effect and the xanthine oxidase inhibition of the leaves extract was 0.960, which indicated that there is a strong relationship between the two said parameters. From the Lineweaver-Burk plot and solver function analysis, the mode of enzyme inhibition was a non-competitive inhibition.
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