Nanoelectronics is the term used in the field of nanotechnology for electronic components and research on improvements of electronics such as display, size, and power consumption of the device for the practical use. This includes research on memory chips and surface physical modifications on the electronic devices. Nanoelectronics cover quantum mechanical properties of the hybrid material, semiconductor, single dimensional nanotubes, nanowires, and so forth. Well-developed nanoelectronics can be applied in different fields, and are especially useful for detecting disease-causing agents and disease biomarkers. As a consequence, point-of-care detection became popularized due to the involvement of nanoelectronics. In this chapter, we discuss documented biosensing applications of nanoelectronics.