In process of the shaping plastic part, the defects always encounter with the produced plastic part shape and functionality are affected by plastic injection molding process. This study is relating to a decreasing warpage and improving the process parameter in injection molding. One of the defects on injected parts is warpage, from a certain path this defect normally produces a band-like shape deviation. The most affected area of this defect is appearance, followed by assembly and also the quality of the product. This study was obtained to minimize the problem faced and getting the optimum result based on the problem facing by previous researchers that have been analyzed to getting the information. Besides that, the software of Autodesk Moldflow Insight (AMI) is used to do a simulation of the analysis. Thus, Design of Experiment (DOE) was used to optimize the result which is Response Surface Methodology (RSM). For the comparison, Differential Evolution (DE) approach will be used in combination with AMI and RSM result. The best combination of parameter setting is gained and effect the warpage to become decreases. To produce good quality of injection molding parts this will be contributed continuous production line run with high accuracy and good parameters setting. Without wasting time and resources, this advance research will contribute to producing a good quality injection molding parts.