Nanoindentation was commonly used to examine the intrinsic (microstructure level) mechanical properties of OI human bone tissue. The findings that available will describe bone material properties with this disorder. This review presents an overview of nanoindentation measurement on Osteogenesis Imperfecta (OI) across OI type, patient age, structure of study and anatomy site. Nanoindentation was capable of probing the mechanical properties of volumes of tissue as small as lamellae. In this technique, an indentation test was performed with a depth sensing indenter tip to measurement. The force displacement results were analyzed to obtain the modulus and hardness. The results of this study indicate that severity of OI type and microstructure level (interstitial and osteonal) had a significant effect on modulus and hardness. While, the age of patient, structure of study, and anatomy site shows non-significant findings were observed in all the measurement for both cortical and trabecular bones.
