Publication:
A pH stimuli thiol modified mesoporous silica nanoparticles: Doxorubicin carrier for cancer therapy

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cris.author.scopus-author-id 7801599209
cris.author.scopus-author-id 57201583340
cris.author.scopus-author-id 57195215587
cris.author.scopus-author-id 36873187500
cris.author.scopus-author-id 16231987300
cris.author.scopus-author-id 7006558013
dc.contributor.author Velusamy P.
dc.contributor.author Srinivasa C.M.
dc.contributor.author Kumar G.V.
dc.contributor.author Qurishi Y.
dc.contributor.author Su C.H.
dc.contributor.author Gopinath S.C.B.
dc.date.accessioned 2025-01-13T14:48:17Z
dc.date.available 2025-01-13T14:48:17Z
dc.date.issued 2018-06-01
dc.description.abstract Mesoporous silica nanoparticles (MSN) have been attracted in the field of biomedicine due to their versatile properties as a drug nanocarrier. In this research, MSN and thiol modified MSN (mMSN) were synthesized to be the drug nanocarriers, by the sol–gel technique for the efficient delivering doxorubicin hydrochloride (DOX). These carriers were characterized by Transmission Electron Microscopy (TEM), Field Emission Scanning Electron Microscopy (FESEM), SA3100 analyzer (Brunauer–Emmett–Teller), Zetasizer and Fourier transform infrared spectroscopy (FTIR). FESEM observation revealed that these particles have uniform sizes and the zeta potential analysis confirmed the existence of surface charge and stability of the particles. Brunauer–Emmett–Teller showed that MSN and mMSN are characteristic type IV N2 adsorption/desorption patterns. The in vitro drug release profile studies have profound that the drug-loaded carriers were pH dependent and the drug-loaded mMSN (DOX@mMSN) displayed a faster drug release at the acidic pH with tumor cells than the pH with normal cells. Cell cycle arrest and ROS generation were analyzed by Fluorescence-activated cell sorting. Assay on the cytotoxicity against the HeLa cells showed a better antitumor effect with DOX@mMSN compared to DOX@MSN. This study attested that pH-responsive thiol modified drug nanocarrier can have the potential cancer therapy.
dc.identifier.doi 10.1016/j.jtice.2018.03.048
dc.identifier.scopus 2-s2.0-85045303392
dc.identifier.uri https://hdl.handle.net/20.500.14170/13429
dc.relation.grantno undefined
dc.relation.ispartof Journal of the Taiwan Institute of Chemical Engineers
dc.relation.ispartofseries Journal of the Taiwan Institute of Chemical Engineers
dc.relation.issn 18761070
dc.subject Doxorubicin hydrochloride | Drug nanocarrier | Mesoporous silica nanoparticles | pH-responsive | Thiol modified silica nanoparticles
dc.title A pH stimuli thiol modified mesoporous silica nanoparticles: Doxorubicin carrier for cancer therapy
dc.type Journal
dspace.entity.type Publication
oaire.citation.endPage 271
oaire.citation.startPage 264
oaire.citation.volume 87
oairecerif.affiliation.orgunit SRM Institute of Science and Technology
oairecerif.affiliation.orgunit SRM Institute of Science and Technology
oairecerif.affiliation.orgunit SRM Institute of Science and Technology
oairecerif.affiliation.orgunit Indian Institute of Science
oairecerif.affiliation.orgunit Ming Chi University of Technology
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
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person.identifier.scopus-author-id 7801599209
person.identifier.scopus-author-id 57201583340
person.identifier.scopus-author-id 57195215587
person.identifier.scopus-author-id 36873187500
person.identifier.scopus-author-id 16231987300
person.identifier.scopus-author-id 7006558013
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