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Sodium alginate/Hydroxyapatite/nanocellulose composites: Synthesis and Potentials for bone tissue engineering

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cris.author.scopus-author-id 58070559000
cris.author.scopus-author-id 50162351800
cris.author.scopus-author-id 7006558013
cris.virtual.department Universiti Malaysia Perlis
cris.virtualsource.department 3f983c2e-28f9-4f7e-9c19-b081a6c20fd8
dc.contributor.author Iswarya S.
dc.contributor.author Theivasanthi T.
dc.contributor.author Subash Chandra Bose Gopinath
dc.date.accessioned 2024-10-04T00:33:55Z
dc.date.available 2024-10-04T00:33:55Z
dc.date.issued 2023-12-01
dc.description.abstract Sodium alginate/hydroxyapatite/Nano cellulose (SA/HA/NC) nanocomposite films that possess good biocompatibility for bone tissue engineering are prepared by a simple solution casting. HA is one of the most frequently used bioceramic materials to achieve a high biocompatibility. The bionanocomposite films are analysed by XRD, SEM, EDAX and FTIR studies. XRD confirms the existence of fillers in the polymer. FTIR spectrum shows the different functional modes in the bionanocomposite films. The morphology of fillers and bionanocomposite films are obtained through SEM. The inclusion of NC with different concentrations into the biopolymer film improves the tensile strength. As a result, the loading of 5 wt % of NC and 10 wt% of HA in the SA polymer shows high tensile strength when compared to the pure SA, SA filled with 10 wt% of HA and SA loaded with 10 wt% of HA and inclusion of NC (0.5 and 2.5 wt%). The tensile strength (TS) of bionanocomposite film with 10 wt % of HA is increased by 17%. TS of bionanocomposite film with 0.5 and 2.5 wt% of NC is increased by 177 and 277%, whereas TS of bionanocomposite film loaded 5 wt% of NC is increased by 331%. The swelling, biodegradation and biomineralization tests suggest that this bionanocomposite films are hopeful biomaterials for bone tissue engineering.
dc.identifier.doi 10.1016/j.jmbbm.2023.106189
dc.identifier.pmid 37852086
dc.identifier.scopus 2-s2.0-85174021525
dc.identifier.uri https://hdl.handle.net/20.500.14170/9217
dc.relation.funding National Research Centre
dc.relation.grantno undefined
dc.relation.ispartof Journal of the Mechanical Behavior of Biomedical Materials
dc.relation.ispartofseries Journal of the Mechanical Behavior of Biomedical Materials
dc.relation.issn 17516161
dc.subject Bionanocomposite | Hybrid materials | Non-metallic | Polymer
dc.title Sodium alginate/Hydroxyapatite/nanocellulose composites: Synthesis and Potentials for bone tissue engineering
dc.type Journal
dspace.entity.type Publication
oaire.citation.volume 148
oairecerif.affiliation.orgunit Kalasalingam Academy of Research and Education
oairecerif.affiliation.orgunit Kalasalingam Academy of Research and Education
oairecerif.affiliation.orgunit Universiti Malaysia Perlis
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation #PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation Universiti Malaysia Perlis
oairecerif.citation.number 106189
person.identifier.orcid #PLACEHOLDER_PARENT_METADATA_VALUE#
person.identifier.orcid #PLACEHOLDER_PARENT_METADATA_VALUE#
person.identifier.orcid 0000-0002-8347-4687
person.identifier.scopus-author-id 58070559000
person.identifier.scopus-author-id 50162351800
person.identifier.scopus-author-id 7006558013
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