Spare parts are used to keep a system functioning, reducing downtime and the system’s life span. Recently, spare parts management has gained significant attention among maintenance departments due to the “right to repair”, which required the provision of readily available spare parts. Therefore, this study focused on identifying critical spare parts for mechanical ventilation and air-conditioning (MVAC) systems. The objectives of this study were to identify the critical spare parts needed in the MVAC system in the university campus and analyze the priority factors affecting the management of these critical spare parts. The Cartesian coordination system based on critical and important has been used to classify spare parts into four quadrants consisting of Indispensable (QA), Imperative Secondary (QB), Unnecessary (QC), and Lower Priority Required (QD). The spare part inventory management and impact of the system have also been examined to be classified into preferred, consistently managed, moderately managed, infrequently managed, and commonly managed. The Cartesian coordination analysis revealed that 19 out of 20 critical spare part components fell into a quadrant of indispensable, which implies that require much attention in the system. In contrast, one component fell within quadrant QD, indicating low importance but functional for the MVAC system. In addition, the combination matrix analysis categorized the components into five classified where 6 components were consistently managed, 11 components were moderately managed and 3 components were infrequently managed in the management of the university campus. The findings are critical for facility management to ensure the reliability and efficiency of the MVAC system and regular monitoring and optimization of spare parts, especially critical parts of the system.