Corpus callosum (CC) is the largest fiber bundle in human brain where it’s connected two cerebral hemispheres. Mainly, these fibers connected homologous cortical areas in nearly mirror-image sites, but a substantial number have heterotopic connections, ending in asymmetrical areas. Corpus collosum act as an integral role in relaying sensory, motor and cognitive information between homologous regions in the two cerebral hemispheres. Using MRI, corpus collosum can be discretely identified at the mid-sagittal level where it crosses the midline and its morphology has been extensively studied. Such studies have shown that the shape of the CC may be related to, handedness and certain disease such as Down’s syndrome. The purpose of this paper is to study whether incorporation of diffusion tensor imaging (DTI) and DTIbased 3D tract information can facilitate the study of anatomical parcellation of intra- corpus collosum structures. The corpus collosum is divided into six sub-regions based on trajectories into subcortical nuclei and the orbital, frontal, parietal, occipital and temporal lobes.
