94With the advent of immersive technologies, it is possible to create unique experiences by combining the physical world with digital reality. Augmented reality (AR), virtual reality (VR), and mixed reality (MR) are examples of digital technologies and affordances that replicate reality in various ways. Immersive technologies in medical science, psychology, and clinical research can help doctors, surgeons, and patients by providing extended reality views. Immersive technologies such as VR and AR play a significant role in developing a stimulating environment. A stimulating environment can help doctors perform surgeries, children with autism disorder develop their communication skills, and psychologists provide simulated situations to patients suffering from different neurological disorders. AR and VR can take patients into similar situations when they face panic attacks, anxiety, and phobia in a controlled manner, which further helps them overcome the situations in real life. In this paper, the possibilities of AR and VR interventions for providing unique solutions in medical science, clinical research, psychology, and neurological disorders are discussed. The most recent studies were selected based on users’ medical and disability needs, and an overview of past research was presented in terms of current work, benefits, obstacles, and opportunities for future work.