Purpose: To present an overview of the ethnopharmacology, phytochemistry, and pharmacological effects of the ‘wonder’ plant, Uncaria gambir (W. Hunter) Roxb. Methods: The literature search for information on phytochemical composition and pharmacological importance of U. gambir was undertaken using diverse electronic search engines, including Google, Scopus, Web of Science, scientific literature, and databases (Pubmed, Springer and Science Direct). Other relevant literature sources include books, book chapters, conference papers, theses, and other scientific publications. Results: Uncaria gambir Roxb possesses significant medicinal potentials as an antioxidant, anthelmintic, antibacterial, anti-diabetic, and for the management of osteoarthritis. Interest has increased among researchers for the utilization of this plant in complementary medicine, for example, to relieve sore throat, spongy gum, and dysentery, to treat atherosclerosis and obesity, and to prolong sexual intercourse. Conclusion: Uncaria gambir demonstrates significant pharmacological properties. This review will be useful for prospective research and development of this ethnomedicinal plant into potentially valuable health products.
