The organizational performance of the garment industry in Bangladesh through human resource management (HRM) practices has received a great deal of attention in recent decades from popular educationalists, human resource management practitioners, and consulting firms and among the garment owners and managers of the garments industries in Bangladesh. The purpose of the present study is to examine the effects of HRM practices on organizational performances of the garment industries in Bangladesh and to determine how workplace safety in the garment industries in Bangladesh plays a moderating role in regards achieve organizational performance. Though there are numerous human resources practices to achieve or attain better organizational performance, yet handpick factors (recruitment and selection, training and development, performance appraisal, and reward and benefits) were selected in the context of Bangladesh and more specifically in the garment industries of Bangladesh. Despite maximum contributions regarding foreign currency earning, employment, women empowerment, and attaining maximum GDP to the economy of Bangladesh through this sector, still the safety concerns of the ready-made garment industry of Bangladesh are very alarming. A total of 400-human resource managers from different garment industries of Bangladesh participated in this study. Data were collected through questionnaires. The Partial Least Squires approach to Structural Equation Modeling (PLS-SEM) was the main statistical technique employed in the study. The findings of the study revealed that recruitment and selection, training and development, performance appraisal, and reward and benefit were found to have significant effects on organizational performance in the garment industries of Bangladesh. The moderator variable of workplace safety was found to have a significant effect between HRM practices and organizational performance. Based on the findings, the theoretical and practical implications, as well as limitations and direction for further research, were also discussed.