Mazlee Mazalan
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Preferred name
Mazlee Mazalan
Official Name
Mazlee, Mazalan
Alternative Name
Mazalan, Mazlee Bin
Mazalan, Mazlee
Main Affiliation
Scopus Author ID
54420543000
Researcher ID
FKZ-3093-2022

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Current development in interdigital transducer (IDT) surface acoustic wave devices for live cell in vitro studies: A review

2022-01-01 , Mazlee Mazalan , Anas Mohd Noor , Yufridin Wahab , Shuhaida Yahud , Zaman W.S.W.K.

Acoustics have a wide range of uses, from noise-cancelling to ultrasonic imaging. There has been a surge in interest in developing acoustic-based approaches for biological and biomedical applications in the last decade. This review focused on the application of surface acoustic waves (SAW) based on interdigital transducers (IDT) for live-cell investigations, such as cell manipulation, cell separation, cell seeding, cell migration, cell characteristics, and cell behaviours. The approach is also known as acoustofluidic, because the SAW device is coupled with a microfluidic system that contains live cells. This article provides an overview of several forms of IDT of SAW devices on recently used cells. Conclusively, a brief viewpoint and overview of the future application of SAW techniques in live-cell investigations were presented.

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A Numerical Study of Collective Cell Migration in a Microchannel Driven by Surface Acoustic Wave (SAW) Device

2023-01-01 , Mazlee Mazalan , Anas Mohd Noor , Yufridin Wahab , Shazlina Johari , Mohd Rosydi Zakaria , Zaman W.S.W.K.

Collective cell migration is involved in a variety of biological contexts, including tissue morphogenesis, wound healing, and cancer invasion. Many studies have revealed that chemical, mechanical, and electrical stimulation all affect cell migration. Although an acoustic stimulus has been shown to influence cell migration in the past, the underlying mechanism is still unknown. A computational model that accounts for acoustic-structure interaction was constructed in this study to simulate the formation of a surface acoustic wave (SAW) field and the application of the acoustic pressure field on collective cell migration. A group of cells within a microchannel device and two ports of interdigitated transducers (IDTs) with different wavelengths were modeled. The stresses within cells were investigated as it was influenced by substrate displacement and pressure acoustic in the cell media generated by the SAW device. As a result, we observed the local stress within cells near the solid-fluid interfaces. For propagating SAW, the shorter wavelength of IDTs (600 μm) attributed to high stress at the cell's top and bottom as compared to the SAW device with the longer wavelength (1000 μm). The standing SAW occurred underneath collective cells. The results of standing SAW on cell stress at the bottom confirm that the SAW device can be useful to regulate the abnormalities cellular activities associated with cell migration.

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