Adibah Izzati Daud
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Adibah Izzati Daud
Official Name
Adibah Izzati, Daud
Alternative Name
Daud, Adibah Izzati
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Scopus Author ID
55764818200
Researcher ID
O-5684-2016

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  • Publication
    Bringing forward the new generation of alkoxy-thiourea as potential treatment for Acanthamoeba keratitis
    ( 2017-02-21)
    Wan M. Khairul
    ;
    Yit Peng Goh
    ;
    Adibah Izzati Daud
    ;
    Nakisah M.A.
    Alkoxy substituted thiourea derivatives with general formula of A-ArC(O)NHC(S)NHAr-D which A represents the methoxy group and D denotes -OCnH2n+1 have been successfully synthesised and characterized. In turn, all the synthesised molecules were assayed for anti-amoebic activities towards Acanthamoeba sp to examine the cytotoxicity effect at their IC50 and membrane permeability. As predicted, the findings showed that the synthesised molecules owing promising anti-amoebic activity towards Acanthamoeba sp. To support, the Acridine-orange/Propidium iodide (AOPI) staining result under fluorescence microscopy revealed the treated amoeba cells by these alkoxy thiourea derivatives exhibited loss in their membrane permeability.
      19  2